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ReviewAnnals of medicine2025

Antimicrobial resistance to colistin in neonates: epidemiological insights and public health implications in Nigeria - a mini review.

Adewunmi Akingbola, Abiodun Christopher Adegbesan, Olaoluwa Olorunfemi, Kolade Adegoke, Kehinde Abereoje, Olajumoke Adewole, Victor Olamide Oluwasola, Somadila Igboanugo, Ademola Aiyenuro

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PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Colistin-resistance amongJAC-antimicrobial resistance · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adewunmi AkingbolaDepartment of Public Health and Primary Care, University of Cambridge Old Schools Trinity Lane CB2 1TN Cambridgeshire England, UK.ORCID 0000-0001-7245-0340
Abiodun Christopher AdegbesanAfrican Cancer Institute, Department of Global Health, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0001-9478-5360
Olaoluwa OlorunfemiDepartment of Family Medicine, Bowen University Teaching Hospital, Nigeria, Ogbomosho Oyo State.ORCID 0009-0007-9174-7802
Kolade AdegokeFaculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.ORCID 0009-0006-1509-0274
Kehinde AbereojeDepartment of Public Health, University of Cambridge Cambridgeshire Old Trinity Schools, England, UK.ORCID 0009-0008-3840-9342
Olajumoke AdewoleDepartment of Community Health and Primary Healthcare, Lagos State University College of Medicine, Ikeja, Lagos State.ORCID 0009-0000-6372-2316
Victor Olamide OluwasolaBabcock University Teaching Hospital, Ilishan-Remo, Ogun State, Nigeria.
Somadila IgboanugoRostov State Medical University, Rostov-on-Don, Russia.ORCID 0009-0006-3656-9591
Ademola AiyenuroDivision of Virology, Department of Pathology, University of Cambridge, England, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

backgroundAntimicrobial resistance (AMR) remains a critical global health issue, particularly in low- and middle-income countries like Nigeria. Colistin, a last-resort antibiotic for multidrug-resistant Gram-negative infections, has seen rising resistance, posing a significant challenge for neonatal sepsis management. This narrative review focuses on colistin resistance in neonates in Nigeria, addressing a critical public health threat. With rising antimicrobial resistance, understanding its epidemiology in vulnerable populations is essential for effective interventions.

methodsA narrative mini-review was conducted, focusing on literature, systematic reviews, and global and national reports on colistin resistance in neonates. Data were synthesized from studies across Africa, with an emphasis on epidemiological insights and implications for public health in Nigeria.

resultsThe review identified an increasing trend of colistin resistance in Gram-negative bacteria in neonates across Nigeria. Key findings highlight the presence of mobile colistin resistance (MCR) genes, such as mcr-1, in clinical isolates from neonates, despite limited exposure to colistin. The analysis also emphasized the limitations in screening practices and gaps in neonatal AMR surveillance in Nigeria. The results suggest that inadequate antimicrobial stewardship, overuse of antibiotics, and poor healthcare infrastructure contribute to the rapid emergence of colistin resistance in neonates.

conclusionColistin resistance in neonates poses a grave threat to public health. Addressing this issue requires urgent improvements in antimicrobial stewardship, neonatal care, and AMR surveillance systems. Strengthening laboratory capacities, improving infection prevention practices, and global cooperation are critical to mitigating the spread of colistin-resistant infections in neonates and reducing mortality in low-resource settings.

Indexed as

Anti-Bacterial AgentsColistinDrug Resistance, BacterialGram-Negative BacteriaGram-Negative Bacterial InfectionsNeonatal SepsisAntimicrobial StewardshipDrug Resistance, Multiple, BacterialHumansInfant, NewbornNigeriaPublic HealthAnti-Bacterial AgentsColistinanti-bacterial agentsantimicrobial resistancebacterialColistindrug resistanceenterobacteriaceae infectionsmcr-1 gene

Identifiers

PMID40844858
PMCPMC12377088

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.