Evidence map›Paper›PMID 40844831›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Oral Cavity Squamous Cell Carcinoma in Young Patients: A Multi-Institutional Study of the Canadian Head & Neck Collaborative Research Initiative.

Xinyuan Hong, Alexandra E Quimby, Dorsa Mavedatnia, A Travis Pickett, Martin Corsten, Tinghua Zhang, Angelina Tohme, Stephanie Johnson-Obaseki, Carlos Khalil, Mark Khoury and 22 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Modulation ofInternational journal of molecular sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Xinyuan HongDepartment of Otolaryngology-Head and Neck Surgery, The University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Alexandra E QuimbyDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Dorsa MavedatniaOtolaryngology-Head & Neck Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
A Travis PickettDepartment of Otolaryngology-Head and Neck Surgery, The University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Martin CorstenDivision of Otolaryngology-Head and Neck Surgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada.
Tinghua ZhangThe Ottawa Hospital Research Institute, The Clinical Epidemiology Program, The Ottawa Hospital, Ottawa, ON, Canada.
Angelina TohmeDepartment of Otolaryngology-Head and Neck Surgery, The University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.ORCID 0009-0003-8174-3577
Stephanie Johnson-ObasekiDepartment of Otolaryngology-Head and Neck Surgery, The University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Carlos KhalilDepartment of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
Mark KhouryDepartment of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
Antoine EskanderDepartment of Otolaryngology-Head and Neck Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
Hesameddin NorooziDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre- University Health Network, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
David GoldsteinDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre- University Health Network, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
John De AlmeidaDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre- University Health Network, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
James FowlerDepartment of Otolaryngology-Head and Neck Surgery and Oncology, London Health Sciences Center, London, ON, Canada.
S Danielle MacNeilDepartment of Otolaryngology-Head and Neck Surgery and Oncology, London Health Sciences Center, London, ON, Canada.
Anthony C NicholsDepartment of Otolaryngology-Head and Neck Surgery and Oncology, London Health Sciences Center, London, ON, Canada.
Joseph DortDivision of Otolaryngology-Head and Neck Surgery, University of Calgary, Calgary, AB, Canada.
Robert HartDivision of Otolaryngology-Head and Neck Surgery, University of Calgary, Calgary, AB, Canada.
Wayne MatthewsDivision of Otolaryngology-Head and Neck Surgery, University of Calgary, Calgary, AB, Canada.
Apostolos ChristopoulosDivision of Otolaryngology - Head and Neck Surgery, University of Montreal Hospital Center (CHUM), Montréal, QC, Canada.
Gabriel DayanDivision of Otolaryngology - Head and Neck Surgery, University of Montreal Hospital Center (CHUM), Montréal, QC, Canada.ORCID 0000-0001-7594-4522
Houda BahigDepartment of Radiation Oncology, CHUM, Université de Montreal, Montreal, QC, Canada.
Michael P HierDepartment of Otolaryngology - Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Khalil SultanemDepartment of Radiation Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Gregoire B MorandDepartment of Otolaryngology - Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Brigitte Routhier-ChevrierDepartment of Otolaryngology - Head and Neck Surgery, University of Sherbrooke, Sherbrooke, QC, Canada.
Zhi Shuo ZhangDepartment of Otolaryngology - Head and Neck Surgery, University of Sherbrooke, Sherbrooke, QC, Canada.
Mathieu BelzileDepartment of Otolaryngology - Head and Neck Surgery, University of Sherbrooke, Sherbrooke, QC, Canada.
Hamza LarefDepartment Otolaryngology-Head and Neck Surgery, Hôpital Maisonneuve-Rosemont, Université de Montreal, Montreal, QC, Canada.
Marie-Jo OlivierDepartment Otolaryngology-Head and Neck Surgery, Hôpital Maisonneuve-Rosemont, Université de Montreal, Montreal, QC, Canada.
Anastasios ManiakasDepartment Otolaryngology-Head and Neck Surgery, Hôpital Maisonneuve-Rosemont, Université de Montreal, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ImportanceOral cavity squamous cell carcinoma (OCSCC) is rare in patients ≤40 years, and their risk factors, presentation, and outcomes may differ from older patients.ObjectiveTo assess the epidemiology, risk factors, and oncologic outcomes of young patients (≤40 years) with OCSCC compared to those >40 years.DesignA multi-institutional retrospective cohort study.SettingNine Canadian institutions from 2005 to 2019.ParticipantsIn total, 4506 adults with OCSCC, of whom 205 (4.55%) were young and 4301 were older than 40.Interventions or ExposuresThe primary outcomes were overall survival (OS) and disease-free survival (DFS), comparing young and older patients. The identification of risk factors for OCSCC development in young patients was a secondary outcome.Main Outcome MeasuresOS, DFS, and risk factor identification.ResultsOral tongue cancer was the most common subsite (48.9%), with a significantly higher proportion of cases in young patients (73.4% vs 47.7%,

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsSquamous Cell Carcinoma of Head and NeckAdultAgedAge FactorsCanadaDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesRisk FactorsSurvival Ratehead and neckhead and neck (malignancy)oral cavityoropharynxpediatric generalpediatrics

Identifiers

PMID40844831
PMCPMC12374110

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.