Evidence map›Paper›PMID 40844802›Full record

ArticleJournal of environmental science and health. Part C, Toxicology and carcinogenesis2025

Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen.

Xiaoqing Guo, Ji-Eun Seo, Jaime Miranda-Colon, Hannah Xu, Javier Revollo, Robert H Heflich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoqing GuoDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.ORCID 0000-0001-5951-2156
Ji-Eun SeoDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.ORCID 0009-0002-3420-1954
Jaime Miranda-ColonDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.ORCID 0009-0000-0780-7585
Hannah XuDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.ORCID 0000-0002-7969-7431
Javier RevolloDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.ORCID 0000-0003-0518-2096
Robert H HeflichDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.ORCID 0000-0001-6244-1774

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Accurately evaluating chemical risk may benefit from the development of human-relevant models capable of capturing the effects of treatments that closely mimic real-world environmental and pharmaceutical exposures. Building on our previous work (Seo et al. Arch Toxicol 98:1919-1935),

Indexed as

CarcinogensDimethylnitrosamineDNA DamageMutagensMutationHumansMicronucleus TestsCarcinogensDimethylnitrosamineMutagens3D spheroidserror-corrected sequencinggenotoxicityHepaRG cellsmutation

Identifiers

PMID40844802
PMCPMC12401553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.