Evidence map›Paper›PMID 40844793›Full record

ReviewClinical & experimental metastasis2025

Prognostic influence of chronic inflammation in patients with head and neck cancer based on sex differences.

Claudia Antwi-Boasiako, Orr Dimitstein, Sophia Chehade, Fatemeh Farshadi, Michael Hier, Marco A Mascarella, Alex Mlynarek, Moulay A Alaoui-Jamali, Sabrina Daniela da Silva

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & experimental metastasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claudia Antwi-BoasiakoDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Orr DimitsteinDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Sophia ChehadeDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Fatemeh FarshadiDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Michael HierDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Marco A MascarellaDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Alex MlynarekDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada.
Moulay A Alaoui-JamaliSegal Cancer Centre and Lady Davis Institute for Medical Research of Sir Mortimer B. Davis-Jewish Hospital, Montreal, QC, H3A 0G4, Canada.
Sabrina Daniela da SilvaDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada. sabrina.wurzba@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancer (HNC) is the 7th most common cancer globally. Despite a growing interest of the impact of hormone-specific factors on cancer biology, there is limited understanding of whether the inflammatory microenvironment exhibits significant prognostic differences based on the sex of the patients with HNC. This scoping literature review evaluates if the inflammatory microenvironment exhibits significant variations between male and female patients with HNC. By compiling data from 17 datasets involving 4907patients from seven countries, we confirmed a lower incidence of HNC in females compared to males. However, only few publications addressed the specific effects of endogenous and exogenous hormones remodeling the tumor microenvironment and/or genetic predispositions. Considering sex as a biological variable, the association of various immune and blood vascular cell populations within the tumor microenvironment (including T cells, B cells, macrophages, neutrophils, and blood vessels) was validated in relation to disease progression and metastasis using The Cancer Genome Atlas (TCGA) database for head and neck cancer (Firehose Legacy, n = 528 patients). The outcome is that inflammatory factors associated with sex-specific differences influence the prognostic disparities between males and females. Delineating the molecular mechanisms involved is crucial for advancing precision medicine and tailoring treatment strategies to optimize existing therapies, ultimately improving the overall management and outcomes of HNC patients with aggressive disease.

Indexed as

Head and Neck NeoplasmsInflammationTumor MicroenvironmentChronic DiseaseFemaleHumansMalePrognosisSex CharacteristicsSex FactorsHead and neck cancerInflammationManagementPrognosisSex differencesSquamous cell carcinoma

Identifiers

PMID40844793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.