Evidence map›Paper›PMID 40844742›Full record

ArticleScience China. Life sciences2026

Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator.

Caihong Weng, Xin Pu, Ruohao Tang, Yejun Han

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caihong WengState Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Xin PuState Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Ruohao TangState Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Yejun HanState Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. yjhan@ipe.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanin is an advanced polymer with exceptional properties, widely used across cosmetics, pharmaceuticals, environmental applications, and more. However, its broader use is constrained by high production costs and limited availability. Lignin, the most abundant and renewable aromatic compound in nature, presents a promising alternative for synthesizing melanin. This study focuses on converting plentiful and cost-effective lignin into melanin through the metabolic engineering of Cupriavidus necator H16. By constructing and optimizing metabolic pathways, engineered C. necator strains were developed to synthesize melanin from lignin monomers and lignin hydrolysates. Using substrates like p-coumaric acid, caffeic acid, ferulic acid, and lignin hydrolysates, the resting cell method with C. necator produced 0.86, 1.00, 0.52, and 0.32 g L

Indexed as

Cupriavidus necatorLigninMelaninsMetabolic EngineeringCoumaric AcidsHydrolysisCoumaric Acidsferulic acidLigninMelaninsp-coumaric acidCupriavidus necatorlignin hydrolysatesmelanin biosynthesismetabolic engineering

Identifiers

PMID40844742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.