Evidence map›Paper›PMID 40844693›Full record

ArticleVeterinary medicine and science2025

Therapeutic Effect of Barberry (Berberis vulgaris) Root Extract on Experimental Cutaneous Leishmaniosis in a BALB/c Mouse Model.

Sadegh Shirian, Morteza Norouzi Cholcheh, Saeed Habibian Dehkordi, Behnam Bakhtiari Moghadam

Abstract read
In one paragraph

Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sadegh ShirianDepartment of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.ORCID https://orcid.org/0000-0003-4137-9056
Morteza Norouzi CholchehDepartment of Clinical Science, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Saeed Habibian DehkordiDepartment of Basic sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Behnam Bakhtiari MoghadamDepartment of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.ORCID https://orcid.org/0000-0003-4530-1125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bioactive compounds derived from plants offer promising avenues for discovering new treatments for various types of leishmaniasis. Approximately 22 alkaloids have been identified in different parts of the barberry plant, particularly in the roots. This study aimed to investigate the therapeutic effects of barberry (Berberis vulgaris) on the treatment of experimental cutaneous leishmaniasis (CL) caused by Leishmania major in a BALB/c mouse by using pathological, immunohistochemical, and clinical methods. Thirty BALB/c mice, aged 6-8 weeks, were purchased from the Razi Animal Laboratory at Karaj Institute and allowed for adaptation by 1 week. The mice were divided into three groups including control, treatment, and vehicle groups. Animals of both treatment and vehicle groups received a subcutaneous injection of 0.1 mL culture medium containing 2 × 10

Indexed as

BerberisLeishmania majorLeishmaniasis, CutaneousPlant ExtractsAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred BALB CPlant RootsPlant Extractsbarberry rootcutaneous leishmaniasiscytokineextract

Identifiers

PMID40844693
PMCPMC12372602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.