Trial reportInternational journal of colorectal disease2025
Unveiling the impact of body mass index on surgical difficulty and oncological prognosis in low rectal cancer: post-hoc analysis of the LASRE trial.
Trial report in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interpretable machine learning model for predicting operative difficulty in robotic total mesorectal excision for mid-low rectal cancer.Journal of robotic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeThis post-hoc analysis of the LASRE trial aims to evaluate the impact of body mass index (BMI) on surgical difficulty and oncological outcomes in patients undergoing laparoscopic or open resection for low rectal cancer.
methodsThe LASRE trial was a multicenter, randomized controlled trial comparing laparoscopic and open surgery for low rectal cancer. Patients aged 18-75 years with rectal adenocarcinoma located within 5 cm of the dentate line were enrolled and stratified into four BMI groups: underweight (BMI < 18.5 kg/m
resultsA total of 1,039 patients were included. Obese patients exhibited significantly longer operative times (P < 0.001) and higher intraoperative blood loss (P = 0.001). The 30-day complication rate (P = 0.030) and Clavien-Dindo classification (P = 0.040) differed significantly between groups. However, CRM positivity rates did not significantly differ between BMI groups (P = 0.42). During the median follow-up of 36 months, the 3-year OS rate was comparable across BMI groups (P = 0.709), and the 3-year DFS rate showed no significant differences among the BMI groups (P = 0.966).
conclusionsHigher BMI increases surgical difficulty and postoperative complications in low rectal cancer but does not significantly impact CRM positivity or DFS. These findings underscore the importance of considering BMI in surgical planning and patient counseling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.