Evidence map›Paper›PMID 40844614›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Predictive factors in the management of hydrocephalus and cerebrospinal fluid-related complications in pediatric choroid plexus tumors: a single-center experience.

Mahmoud Abbassy, Abdelrhman Enayet, Mohammad Elbaroody, Ahmed Atallah, Madiha Awad, Hala Taha, Mohamed Saad Zaghloul, Amal Refaat, Mohamed ElBeltagy

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Mahmoud AbbassyDepartment of Neurosurgery Children's Cancer Hospital, Egypt and Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Abdelrhman EnayetDepartment of Neurosurgery Children' Cancer Hospital, Egypt and Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohammad ElbaroodyDepartment of Neurosurgery Children' Cancer Hospital, Egypt and Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed AtallahDepartment of Neurosurgery Children' Cancer Hospital, Egypt and Faculty of Medicine, Cairo University, Cairo, Egypt.
Madiha AwadDepartment of Pediatric Oncology Children's Cancer Hospital, National Cancer Institute, Cairo University, Cairo, Egypt.
Hala TahaDepartment of Pathology, Children's Cancer Hospital and National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed Saad ZaghloulDepartment of Radiation Oncology Children's Cancer Hospital, National Cancer Institute, Cairo University, Cairo, Egypt.
Amal RefaatDepartment of Radiodiagnosis, Children' Cancer Hospital and National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed ElBeltagyDepartment of Neurosurgery Children' Cancer Hospital, Egypt and Faculty of Medicine, Cairo University, Cairo, Egypt. beltagy_mohamed@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe intimate relation between hydrocephalus and pediatric choroid plexus tumors (CPTs) should receive special care owing to the high incidence of permanent cerebrospinal fluid (CSF) diversion in those patients. To our knowledge, this is the first study that analyzes predictive factors linked to permanent CSF diversion in children with CPTs.

methodsWe included all cases that were treated between January 2012 and December 2022 upfront in our institute, with a follow-up from 12 to 106 months. Children in whom ventriculoperitoneal shunts were placed before tumor excision were excluded. Demographic data, radiological findings, operative details, and postoperative management of hydrocephalus and CSF-related complications were reviewed.

resultsA total of 80 children with CPTs were included in our study; 58 children (72.5%) needed permanent CSF diversion methods. CSF permeation in FLAIR/T2 sequence (p-value 0.05), longer duration of external ventricular drainage (p-value 0.032), and horn entrapment (p-value 0.03) were related to permanent CSF diversion. Location of the tumor, maximum tumor diameter, consistency, preoperative Evan's index, and amount of blood in the ventricles were not statistically significant. We found that tumor pathology, parenchymal invasion, and extent of resection were statistically significant factors in relation to postoperative entrapment (p-values = 0.016, 0.001, 0.042).

conclusionHydrocephalus has an intimate relationship with pediatric choroid plexus tumors. Placement of a shunt could be inevitable at the end for most of them. However, transependymal CSF permeation in preoperative imaging, duration of EVD placement, and entrapment due to parenchymal invasion or high-grade disease are associated with higher rates of CSF diversion.

Indexed as

Choroid Plexus NeoplasmsDisease ManagementHydrocephalusPostoperative ComplicationsAdolescentCerebrospinal Fluid ShuntsChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantMaleRetrospective StudiesVentriculoperitoneal ShuntAtypicalCarcinomaChoroid plexusHydrocephalusPapilloma

Identifiers

PMID40844614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.