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ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Barriers and solutions for global access to osteoporosis management: a Position Paper from the International Osteoporosis Foundation.

Nicholas C Harvey, Nasser Al-Daghri, Charlotte Beaudart, Maria Luisa Brandi, Nansa Burlet, Claudia Campusano, Etienne Cavalier, Manju Chandran, Cyrus Cooper, Bess Dawson-Hughes and 11 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Revised Swedish FRAX models and the establishment of age-dependent intervention thresholds.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  8. Consensus statement on the application of artificial intelligence in osteoporosis screening and management: perspectives from the Asia-Pacific region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Anabolic-first therapy and planned sequential care in very-high-risk fracture patients: leveraging the REFRA FLS-SEIOMM signal for global implementation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  13. Article
  14. Deltoid Tuberosity Index as a Predictor of Hip Fracture Risk in Older Adults.Geriatric orthopaedic surgery & rehabilitation · 2026
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nicholas C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. nch@mrc.soton.ac.uk.ORCID http://orcid.org/0000-0002-8194-2512
Nasser Al-DaghriChair for Biomarkers of Chronic Diseases, Biochemistry Dept., College of Science, King Saud University, 11451, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0001-5472-1725
Charlotte BeaudartPublic Health Aging Research & Epidemiology (PHARE) Group, Research Unit in Clinical Pharmacology and Toxicology (URPC), Department of Biomedical Sciences- Faculty of Medicine, NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium.ORCID http://orcid.org/0000-0002-0827-5303
Maria Luisa BrandiFirmoLab, FIRMO Foundation, Florence, Italy.ORCID http://orcid.org/0000-0002-8741-0592
Nansa BurletResearch Unit in Epidemiology, Public Health and Health Economics, University of Liège, Liège, Belgium.
Claudia CampusanoClínica Universidad de los Andes and Faculty of Medicine, Universidad de los Andes, Santiago, Chile.ORCID http://orcid.org/0000-0001-5483-9301
Etienne CavalierDepartment of Clinical Chemistry, CIRM, University of Liège, CHU de Liège, Liège, Belgium.
Manju ChandranOsteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
Cyrus CooperMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0003-3510-0709
Bess Dawson-HughesJean Mayer USDA HUMAN Nutrition Research Center On Aging at Tufts University, Boston, MA, USA.
Philippe HalboutInternational Osteoporosis Foundation, Nyon, Switzerland.
Teréza HoughNational Osteoporosis Foundation of South Africa (NOFSA), Cape Town, South Africa.
Marise Lazaretti-CastroMetabolic Bone Diseases Unit, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Radmila MatijevicFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-4993-9399
Ambrish MithalInstitute of Diabetes and Endocrinology, Max Healthcare, New Delhi, 110017, India.ORCID http://orcid.org/0000-0002-0822-3212
Ngozi NjezeDepartment of Radiation Medicine, University of Nigeria Medical School, Enugu Campus- Nsukka, Nigeria.ORCID http://orcid.org/0000-0003-2400-835X
René RizzoliGeneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-1537-422X
Yousef SalehHealth Oasis Hospital Riyadh, Riyadh, Saudi Arabia.
John A KanisCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0002-3129-4326
Kate WardMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-7034-6750
Eugene McCloskeyMellanby Centre for Musculoskeletal Research, Division of Clinical Medicine, School of Medicine and Population Health, Sheffield, UK.ORCID http://orcid.org/0000-0003-0177-8140

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our ability to optimally manage bone health across the lifecourse, and so minimise the risk of fractures, has advanced substantially in recent decades. Whilst fractures and osteoporosis in older age were historically viewed simply as inherent in normal ageing, they are now recognised as manifestations of age-related disease. Key to advancing the field was the development of conceptual (relating to impaired bone mass and microarchitecture with increased propensity to fracture), and subsequent World Health Organization densitometric definitions of osteoporosis, cementing the role of dual-energy X-ray absorptiometry in bone health management. However, whilst low bone mineral density is a strong risk factor for fracture, many individuals who do fracture have normal or only modestly reduced bone mineral density. Furthermore, the existence of two definitions constituting a condition called "osteoporosis", one based on a measurement, and the other conceptual, has led to uncertainty in clinical practice. The field is therefore moving towards calculation of an individual's absolute fracture risk, based on clinical risk factors, with the option to incorporate bone mineral density (if available) as a risk factor rather than as an indication for treatment. Uptake of this new direction has been variable internationally, with many parts of the world, particularly low- and middle-income countries, still predicating treatment (where osteoporosis services exist) on bone mineral density, despite poor availability of densitometry in many such settings. In this Position Paper, on behalf of the International Osteoporosis Foundation, we review the current barriers which prevent equitable access to optimal bone health management worldwide and recommend potential solutions which might be implemented to overcome them.

Indexed as

Health Services AccessibilityOsteoporosisAbsorptiometry, PhotonBone DensityGlobal HealthHumansOsteoporotic FracturesRisk AssessmentRisk FactorsAccessBone healthEpidemiologyInequityManagementOsteoporosis

Identifiers

PMID40844608
PMCPMC12460584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.