ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
High-intensity ethanol binge drinking pattern in adolescence induces long-lasting impairment in the salivary glands and saliva quality of rats.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Prenatal binge-like ethanol exposure induces long-lasting hippocampal oxidative stress, altered inflammatory responses, and memory impairment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Atenolol is associated with salivary gland dysfunction and sialochemical alterations, along with redox imbalance and structural changes in male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Integrated in silico docking, ADMET, and network pharmacology evaluation of Althaea officinalis L. phytocompounds targeting Park2 for the management of Parkinson's disease.Inflammopharmacology · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effects of high-intense ethanol consumption during abstinence periods on the biochemical and morphological profile of the salivary glands and saliva of rats. For this, 72 male rats, 35 days old, exposed to ethanol (20% w/v) in 4 cycles of binge drinking at a dose of 3 g/kg/day were used. The animals were evaluated 1 day after the last cycle, as well as 30 and 60 days of abstinence. The parotid and submandibular glands were collected for oxidative biochemical and morphological analysis while saliva for antioxidant and total protein analysis. Student's t-test was used for statistical comparisons of each analysis period (p = 0.05). In the parotid, when compared with the control group, an increase in reduced glutathione was observed in 60 days (p = 0.04), a decrease in total antioxidant capacity in 1 day (p = 0.007), 30 days (p = 0.006) and 60 days (p = 0.001) were observed, as well as an increase in lipid peroxidation (p = 0.009) and nitric oxide (p < 0.0001) in 60 days. Morphologically, there was a reduction in the area of acini in 1, 30, and 60 days (p < 0.05). In the submandibular, there was an increase in lipid peroxidation in 1 day (p = 0.0197) and nitric oxide in 1 and 30 days (p < 0.0001). Regarding morphological changes, a reduction in the area of acini and an increase in stroma were observed at 1 and 60 days (p < 0.0001). It was concluded that exposure to ethanol during adolescence generates prolonged biochemical and morphological changes in the salivary glands and the saliva.
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Registered trials
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