ArticleThe American journal of gastroenterology2026
Effect of Oral Proton-Pump Inhibitor Administration on Reducing the Delayed Bleeding Risk in 5 Upper Gastrointestinal Endoscopic Treatments.
Article in The American journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Establishment and validation of a predictive scoring system for titanium clip retention at six months after endoscopic submucosal dissection for gastric lesions.Scientific reports · 2026Article
- Recent Advances in Endoscopic Submucosal Dissection for Gastric Cancer: Focusing on Expanded Indications and Technological Innovations.Journal of gastric cancer · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
introductionAlthough proton-pump inhibitor (PPI) is often prescribed for reducing delayed bleeding in upper gastrointestinal endoscopic treatments, no studies with a sufficient sample size evaluated its reduced effect compared with the absence of acid-suppressive agents. The aim of this study was to investigate the effect of oral PPI on reducing delayed bleeding in 5 upper gastrointestinal endoscopic treatments.
methodsThis population-based cohort study collected data from patients who were either prescribed with PPIs or received no acid-suppressive therapy and who underwent esophageal endoscopic mucosal resection (E-EMR), esophageal endoscopic submucosal dissection (E-ESD), gastric endoscopic mucosal resection (G-EMR), gastric endoscopic submucosal dissection (G-ESD), or percutaneous endoscopic gastrostomy (PEG) in Japan between 2012 and 2022 from the Diagnosis Procedure Combination database. The primary outcome was delayed bleeding in each procedure. We conducted propensity score matching to balance 2 comparison groups and performed logistic regression analyses to compare bleeding outcomes.
resultsThis study included data on 172,635 patients. After propensity score matching, the delayed bleeding risk with PPI use was significantly lower in G-EMR (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.52-0.84) and G-ESD (OR, 0.39; 95% CI, 0.30-0.50). By contrast, a lower delayed bleeding risk of PPI was not observed in E-EMR (OR, 1.05; 95% CI, 0.56-1.99), E-ESD (OR, 1.09; 95% CI, 0.86-1.38), and PEG (OR, 1.03; 95% CI, 0.93-1.13). The subgroup and sensitivity analyses almost consistently confirmed the main results. DISCUSSION: Oral PPI administration contributed to reducing delayed bleeding risk in G-EMR and G-ESD but not in E-EMR, E-ESD, and PEG.
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