Evidence map›Paper›PMID 40844477›Full record

Observational studyAntimicrobial agents and chemotherapy2025

Population pharmacokinetic analysis of letermovir in adult hematopoietic cell transplant recipients.

Léna Royston, Carla Kunz, David Tonoli, Pierre Lescuyer, Dionysios Neofytos, Verena Gotta

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Léna RoystonDivision of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland.ORCID 0000-0003-2367-7682
Carla KunzDivision of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.
David TonoliDivision of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Pierre LescuyerDivision of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Dionysios NeofytosDivision of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland.
Verena GottaDivision of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.

Funding

Swiss National Science Foundation 223662
6 · The paper itself

Abstract

We analyzed previously reported oral letermovir plasma concentration measurements from 40 allogeneic hematopoietic cell transplant (HCT) recipients using model-based pharmacometrics analysis. This analysis highlighted that the industry-sponsored phase III study model significantly over-predicted observed letermovir concentrations. Covariates associated with increased oral clearance (CL/F), possibly contributing to this observation, included: higher weight, younger age, and early use after HCT. The clinical significance and mechanistic explanation of relatively lower real-world exposure remains to be elucidated.

Indexed as

AcetatesAntiviral AgentsHematopoietic Stem Cell TransplantationQuinazolinesAdultAgedFemaleHumansMaleMiddle AgedYoung AdultAcetatesAntiviral AgentsletermovirQuinazolinescytomegalovirushematopoietic cell transplantationletermovirpharmacokinetictherapeutic drug monitoring

Identifiers

PMID40844477
PMCPMC12486851

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.