ArticleJACC. Cardiovascular imaging2025
Ascending Aortic Dimensions and Body Size: Allometric Scaling, Normative Values, and Prognostic Performance.
Article in JACC. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4.Redox biology · 2026Article
- An Overview of the Diagnostic and Treatment Strategies for Aortic Disease.Reviews in cardiovascular medicine · 2026Review
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Authors and funding
14 authors.
Funding
Abstract
backgroundAscending aortic (AscAo) dimensions partially depend on body size. Ratiometric (linear) indexing of AscAo dimensions to height and body surface area (BSA) are currently recommended, but it is unclear whether these allometric relationships are indeed linear.
objectivesThis study aimed to evaluate allometric relations, normative values, and the prognostic performance of AscAo dimension indices.
methodsThe authors studied UK Biobank (UKB) (n = 49,271) and Penn Medicine BioBank (PMBB) (n = 8,426) participants. A convolutional neural network was used to segment the thoracic aorta from available magnetic resonance and computed tomography thoracic images. Normal allometric exponents of AscAo dimensions were derived from log-log models among healthy reference subgroups. Prognostic associations of AscAo dimensions were assessed with the use of Cox models.
resultsAmong reference subgroups of both UKB (n = 11,310; age 52 ± 8 years; 37% male) and PMBB (n = 799; age 50 ± 16 years; 41% male), diameter/height, diameter/BSA, and area/BSA exhibited highly nonlinear relationships. In contrast, the allometric exponent of the area/height index was close to unity (UKB: 1.04; PMBB: 1.13). Accordingly, the linear ratio of area/height index did not exhibit residual associations with height (UKB: R
conclusionsAmong AscAo indices, area/height was allometrically correct, did not exhibit residual associations with body size, and was consistently associated with adverse events.
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