Evidence map›Paper›PMID 40844376›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Femur Shape Changes in Prg4-Deficient Mice: Morphological Insights Into Joint Well-Being.

Anand O Masson, Jay Devine, Nabangshu Das, Clarissa R Coveney, Benedikt Hallgrimsson, Zun Liu, Terence D Capellini, Jeff A Biernaskie, W Brent Edwards, Roman J Krawetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Femur Shape Changes in Prg4-Deficient Mice: Morphological Insights Into Joint Well-Being.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anand O MassonDepartment of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada.
Jay DevineMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.
Nabangshu DasMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.
Clarissa R CoveneyDepartment of Human Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
Benedikt HallgrimssonMcCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.
Zun LiuDepartment of Human Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
Terence D CapelliniDepartment of Human Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
Jeff A BiernaskieDepartment of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0002-0633-0698
W Brent EdwardsDepartment of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada.
Roman J KrawetzDepartment of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0002-2576-4504

Funding

Alberta Innovates - Health Solutions (AIHS)Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2020-05269University of Calgary
6 · The paper itself

Abstract

Many studies have reported on the role of Proteoglycan-4 (PRG4, aka lubricin) in the reduction of friction between cartilage surfaces with a specific focus on chondroprotection within the joint. Disruption of the Prg4 gene in humans and mice leads to premature joint failure, hallmarked by synovial hyperplasia and premature articular cartilage fibrillation. Our group has published extensively using Prg4 knockout mice and has consistently noticed variable distal femoral morphology in these animals when compared to Prg4

Indexed as

Cartilage, ArticularFemurProteoglycansAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutProteoglycan 4Prg4 protein, mouseProteoglycan 4Proteoglycans

Identifiers

PMID40844376
PMCPMC12372646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.