ArticleHuman brain mapping2025
Three-Dimensional Efficient Myelin-Weighted Imaging Utilizing Direct Visualization of Short Transverse Relaxation Time Component (ViSTa).
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Association of Apparent Myelin Water Fraction With Diffusional Kurtosis and Biophysical Modeling Parameters.NMR in biomedicine · 2026Article
- Short T1 Fraction as a Marker of Myelin Content: Evidence from Postmortem MRI and Histology.bioRxiv : the preprint server for biology · 2026Article
- Multi-contrast dual-resolution UTE for myelin fraction mapping and structural imaging.Magma (New York, N.Y.) · 2026Article
- Three-Dimensional Efficient Myelin-Weighted Imaging Utilizing Direct Visualization of Short Transverse Relaxation Time Component (ViSTa).Human brain mapping · 2025Article
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3 authors.
Funding
Abstract
Measuring myelin concentration in the brain has important implications in basic science and clinical practice. In MRI, myelin water imaging (MWI) has been suggested as a surrogate biomarker that provides high sensitivity and specificity for myelin. However, multi-exponential fitting is ill-conditioned, and it is sensitive to noise and artifacts, particularly in vivo. To overcome the ill-conditioned fitting problem, the two-dimensional ViSTa myelin-weighted imaging technique was proposed, and it provides a substantially improved myelin-weighted image. However, it is based on a two-dimensional single-slice acquisition scheme, and it is a limitation. In this study, a whole brain-covered 3D ViSTa sequence, based on a 3D segmented echo planar imaging (EPI) sequence with a pair of slice selective inversion RF pulses, was proposed. To investigate the 3D ViSTa myelin weighted image, the distribution of myelin content in the white matter of the brain was measured using both conventional MWI and ViSTa MWI. The proposed 3D ViSTa method achieves a whole brain-covered (FOV = 240 × 240 × 128 mm
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