Evidence map›Paper›PMID 40844079›Full record

ArticleImmunity, inflammation and disease2025

Development of Thymic Organoids Heterotopically to Educate and Induce T Lymphocytes.

Xiuxia Wang, Shun Yu, Yucheng Qiu, Jun Yang, Fei Liu, Xianyu Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xiuxia WangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Shun YuDepartment of Burns and Plastic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, China.
Yucheng QiuDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Jun YangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Fei LiuDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Xianyu ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.ORCID 0000-0003-0959-0011

Funding

This work was supported by the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, National Natural Science Foundation of China (NO. 82102354, NO. 82102319); the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Specific Research Project for Biomedicine Technology, Agency of Science and Technology, Yunnan Province (NO. 202402AA310072).
6 · The paper itself

Abstract

backgroundVascularized composite allotransplantation (VCA) is a potential treatment for extensive injuries that replaces defects like-with-like, however allografts are immune-rejectable.

methodsThis study developed in vitro thymic organoids and examined whether donor-derived HSCs could be educated in vivo into T lymphocytes via central tolerance. TECs, TMCs, and HSCs from C57BL/7 (CD45.2

resultsIn vitro, TECs, TMCs, and HSCs created thymic aggregates, which became thymic organoids after in vivo transplantation and produced CD8

conclusionThymic organoids heterotopically implanted in vivo can promote heterologous HSC-derived T cell development.

Indexed as

OrganoidsThymus GlandT-LymphocytesAnimalsCoculture TechniquesGraft RejectionMiceMice, Inbred C57BLhematopoietic stem cellsthymic epithelial cellsthymic mesenchymal cellsT lymphocytesvascularized composite allotransplantation

Identifiers

PMID40844079
PMCPMC12371559

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