Evidence map›Paper›PMID 40843965›Full record

SynthesisThe Laryngoscope2026

Materials Employed in Preoperative Embolization for Nasopharyngeal Angiofibroma: A Meta-Analysis.

Pranav A Patel, Angelica M Walker, Shaun A Nguyen, Rodney J Schlosser, Chandler J Curtis, Douglas P Nanu, Akash M Bhat, David White

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pranav A PatelDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0009-0000-0627-5142
Angelica M WalkerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Shaun A NguyenDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-0664-4571
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Chandler J CurtisDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Douglas P NanuDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Akash M BhatDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
David WhiteDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCharacterizing outcomes and complications between preoperative embolization materials in the treatment of JNA to help guide clinical management. DATA SOURCES: PubMed, Scopus, CINAHL, Cochrane databases. REVIEW

methodsThis systematic review involved a search of PubMed, Scopus, CINAHL, and Cochrane databases from inception to March 31, 2025. Meta-analysis of continuous measures (mean) and proportions (%) with a 95% confidence interval (CI) was conducted. Studies were accessed for bias via the JBI appraisal tool.

resultsOf 2690 abstracts screened, 40 studies (N = 448) were included. Mean age was 16.1 years (range: 6-29) with 100% males. Polyvinyl Alcohol (PVA) was the most common type of embolization material (59.2%, 95% CI: 54.6-63.6), followed by cyanoacrylate glue, gelfoam, onyx, and coils. Patients treated with gelfoam were not found to have any complications, and the most intraoperative blood loss [346.7 mL (95% CI: 313.9-661.2)] was followed by coils [7.4%; 515.3 mL (95% CI: 109.2-2417.5)], PVA [13.4%; 455.6 mL (95% CI: 313.9-661.2)], Onyx [27.6%; 493.0 mL (95% CI: 334.9-725.6)], and cyanoacrylate glue [47.8%; 504.8 mL (95% CI: 322.9-789.0)], respectively. TMJ pain, trigeminocardiac reflex, and headaches were the most common embolization complications (10.6%-12.8%).

conclusionStudies have shown that embolization improves outcomes for JNA, but the choice of embolization material remains a topic of debate. This study found PVA is the most commonly utilized material and that there may be differences in outcomes and complications between embolization materials. Additional studies should be conducted to rigorously evaluate the differences.

Indexed as

AngiofibromaEmbolization, TherapeuticNasopharyngeal NeoplasmsPreoperative CareAdolescentAdultBlood Loss, SurgicalChildCyanoacrylatesDimethyl SulfoxideFemaleGelatin Sponge, AbsorbableHumansMalePolyvinyl AlcoholPolyvinylsCyanoacrylatesDimethyl SulfoxideOnyx copolymerPolyvinyl AlcoholPolyvinylscyanoacrolateembolizationgelfoamnasopharyngeal angiofibromaonyxpolyvinyl alcohol

Identifiers

PMID40843965
PMCPMC12793951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.