Evidence map›Paper›PMID 40843900›Full record

ArticleInternational journal of neonatal screening2025

Incidence of Congenital Hypothyroidism Is Increasing in Chile.

Francisca Grob, Gabriel Cavada, Gabriel Lobo, Susana Valdebenito, Maria Virginia Perez, Gilda Donoso

Abstract read
In one paragraph

Article in International journal of neonatal screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francisca GrobDivision of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.ORCID 0000-0001-7685-9311
Gabriel CavadaSchool of Public Health, University of Chile, Santiago 8350533, Chile.
Gabriel LoboMedicina Occidente, San Juan de Dios Hospital, University of Chile, Santiago 8350533, Chile.
Susana ValdebenitoMedicina Occidente, San Juan de Dios Hospital, University of Chile, Santiago 8350533, Chile.
Maria Virginia PerezMedicina Occidente, San Juan de Dios Hospital, University of Chile, Santiago 8350533, Chile.
Gilda DonosoMedicina Occidente, San Juan de Dios Hospital, University of Chile, Santiago 8350533, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital hypothyroidism (CH) is a leading preventable cause of neurocognitive impairment. Its incidence appears to be rising in several countries. We analysed 27 years of newborn-screening data (1997-2023) from the largest Chilean screening centre, covering 3,225,216 newborns (51.1% of national births), to characterise temporal trends and potential drivers of CH incidence. Annual CH incidence was modelled with Prais-Winsten regression to correct for first-order autocorrelation; additional models assessed trends in gestational age, sex, biochemical markers, and aetiological subtypes. We identified 1550 CH cases, giving a mean incidence of 4.9 per 10,000 live births and a significant yearly increase of 0.067 per 10,000 (95 % CI 0.037-0.098;

Indexed as

Chilecongenital hypothyroidismincidence trendsmild CHnewborn screeningthyroid-stimulating hormonetime-series analysis

Identifiers

PMID40843900
PMCPMC12372009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.