Evidence map›Paper›PMID 40843761›Full record

ArticleMedical sciences (Basel, Switzerland)2025

Survival Patterns and Mortality Causes in Patients with Invasive Ependymoma: A Retrospective Cohort Analysis from 2000 to 2019.

Anas Elgenidy, Khaled Saad, Amir Aboelgheet, Eman F Gad, Usama El-Shokhaiby, Thamer A M Alruwaili, Abdelrahman N Abdelal, Kawashty R Mohamed, Mohammad Bazzazeh, Mohamed Hesn and 9 more

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In one paragraph

Article in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Anas ElgenidyDepartment of Neurology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Khaled SaadPediatric Department, Faculty of Medicine, Assiut University, Assiut 71516, Egypt.ORCID 0000-0002-8473-6116
Amir AboelgheetPediatric Department, Faculty of Medicine, Assiut University, Assiut 71516, Egypt.
Eman F GadPediatric Department, Faculty of Medicine, Assiut University, Assiut 71516, Egypt.
Usama El-ShokhaibyDepartment of Neurosurgery, Al Azhar University, Cairo 11884, Egypt.
Thamer A M AlruwailiDepartment of Pediatrics, College of Medicine, Jouf University, Sakaka 75741, Saudi Arabia.
Abdelrahman N AbdelalDepartment of Neurology, Al-Azhar University, Assiut 71111, Egypt.
Kawashty R MohamedDepartment of Neurology, Al-Azhar University, Assiut 71111, Egypt.
Mohammad BazzazehFaculty of Medicine, Alexandria University, Alexandria 21526, Egypt.
Mohamed HesnFaculty of Medicine, Al Azhar University, Damietta 25242, Egypt.
Abdelrahman H ElshimyFaculty of Medicine, Alexandria University, Alexandria 21526, Egypt.
Aya SayedMedical Research Institute, Alexandria University, Alexandria 21526, Egypt.
Sara MagdyFaculty of Medicine, Ain Shams University, Cairo 11591, Egypt.
Doaa Ali GamalDepartment of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut 71516, Egypt.
Amira A ElhoufeyDepartment of Community Health Nursing, Alddrab University College, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0003-4656-5886
Shymaa Adel IsmaelDepartment of Neurosurgery, Al-Azhar University for Girls, Cairo 11754, Egypt.
Ahmed M AfifiDepartment of Surgery, University of Toledo Medical Center, Toledo, OH 44192, USA.
Mohamed Fahmy M IbrahimDepartment of Pediatrics, Al-Azhar University, Assiut 71111, Egypt.
Amany RagabDepartment of Neurology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpendymomas are primary CNS neoplasms that arise from the ependymal cells of the brain and spinal cord, accounting for 3-6% of all CNS tumors.

aimsThis study provides a comprehensive analysis of ependymoma survival patterns and examines non-cancer causes of death in the US.

methodsThis retrospective study used data from SEER 17 registries between 2000 and 2019 to evaluate the incidence of ependymoma, as well as the survival and mortality trends in the US.

resultsA total of 3821 patients were included, with 842 (22%) deaths. The highest mortality was observed in younger patients (<18 years) within one year of diagnosis (SMR, 54.77; 95% CI, 38.95-74.88). Brain and other nervous system cancers were the leading causes of death, followed by non-cancer causes, particularly cerebrovascular diseases, pneumonia, influenza, and septicemia. The survival rates observed at one, three, and five years were 94% (95% CI: 0.94-0.95), 88% (95% CI: 0.87-0.89), and 84% (95% CI: 0.82-0.85), respectively. Conditional survival improved over time, with a three-year conditional relative survival rate of 92% after one year of diagnosis and 96% for those who survived five years.

conclusionThe death rate was highest among pediatric patients under 18 years of age. Cerebrovascular disorders were the leading non-cancer cause of death across all time intervals. The probability of surviving for three years increases for patients who have already survived one, three, or five years post-diagnosis.

Indexed as

EpendymomaAdolescentAdultAgedCause of DeathChildChild, PreschoolFemaleHumansIncidenceInfantMaleMiddle AgedRetrospective StudiesSEER ProgramSurvival Ratecause of deathcentral nervous system neoplasmsependymomamortalitysurvival analysis

Identifiers

PMID40843761
PMCPMC12371993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.