Evidence map›Paper›PMID 40843712›Full record

ArticleBioconjugate chemistry2025

[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems.

Marina Carranza, Ana T Carmona, Celia Maya, Enrique Gil de Montes, Aldrin V Vasco, Gonçalo J L Bernardes, Antonio J Moreno-Vargas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marina CarranzaDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, C/Prof. García González, 1, 41012 Sevilla, Spain.
Ana T CarmonaDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, C/Prof. García González, 1, 41012 Sevilla, Spain.ORCID 0000-0003-1058-7127
Celia MayaInstituto de Investigaciones Químicas (IIQ), Departamento de Química Inorgánica and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Consejo Superior de Investigaciones, Científicas (CSIC) and Universidad de Sevilla, 41092 Sevilla, Spain.ORCID 0000-0002-0651-3793
Enrique Gil de MontesYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.
Aldrin V VascoYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.ORCID 0000-0003-1539-1721
Gonçalo J L BernardesYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.ORCID 0000-0001-6594-8917
Antonio J Moreno-VargasDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, C/Prof. García González, 1, 41012 Sevilla, Spain.ORCID 0000-0002-5771-2012

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Azanorbornadienes (ANDs) containing a bromovinyl sulfone are able to accept a first thiol and, in a further stage, fragment upon reaction with a second thiol. This fragmentation has been studied in a collection of differently substituted ANDs. The substitution pattern of the AND influences the rate of the first thiolation and, specially, the further fragmentation.

Indexed as

Aza CompoundsSulfhydryl CompoundsSulfonesModels, MolecularMolecular StructureAza CompoundsSulfhydryl CompoundsSulfones

Identifiers

PMID40843712
PMCPMC12447399

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.