Evidence map›Paper›PMID 40843622›Full record

ArticleAnalytical chemistry2025

Improvement of Electrospray Ionization Response Linearity and Quantification in Dissolved Organic Matter Using Synthetic Deuterated Internal Standards.

Alexander J Craig, Mustapha A Ganiyu, Lindon W K Moodie, Sofja Tshepelevitsh, Koit Herodes, Heike Simon, Thorsten Dittmar, Jeffrey A Hawkes

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander J CraigAnalytical Chemistry, Department of Chemistry BMC, Uppsala University, Uppsala 75 237, Sweden.ORCID 0000-0002-8107-6378
Mustapha A GaniyuAnalytical Chemistry, Department of Chemistry BMC, Uppsala University, Uppsala 75 237, Sweden.
Lindon W K MoodieDrug Design and Discovery, Department of Medicinal Chemistry, Uppsala University, Uppsala 752 37, Sweden.ORCID 0000-0002-9500-4535
Sofja TshepelevitshInstitute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.ORCID 0000-0002-7734-9310
Koit HerodesInstitute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.ORCID 0000-0003-1763-1784
Heike SimonMarine Geochemistry, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky Universität Oldenburg, Oldenburg 26129, Germany.
Thorsten DittmarMarine Geochemistry, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky Universität Oldenburg, Oldenburg 26129, Germany.ORCID 0000-0002-3462-0107
Jeffrey A HawkesAnalytical Chemistry, Department of Chemistry BMC, Uppsala University, Uppsala 75 237, Sweden.ORCID 0000-0003-0664-2242

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquatic dissolved organic matter (DOM) is an ultracomplex mixture of compounds covering a wide range of masses and with an unknown extent of isomeric complexity, making its structural elucidation and quantification highly challenging. Electrospray ionization high-resolution mass spectrometry (ESI-HRMS) has advanced DOM analysis, but accurate concentration determination remains limited by the lack of a response factor correction. Here, we address this limitation by introducing novel deuterated compounds as internal standards that mimic DOM structures. Using a

Identifiers

PMID40843622
PMCPMC12409698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.