ReviewHuman reproduction open2025
The impact of
Review in Human reproduction open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Temporal dynamics of Sertoli and germ cell development in human foetal and prepubertal testis.Biology open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
study questionDoes cancer treatment during pregnancy affect gonadal development in the exposed foetus? SUMMARY ANSWER: Our systematic review revealed that exposure WHAT IS KNOWN ALREADY: It is well known that many cancer therapies can have a detrimental impact on the fertility of children and young people who have been treated for cancer. However, it is not yet known how much these agents impact the gonadal development and subsequent fertility of an STUDY DESIGN SIZE DURATION: We conducted a systematic review, following PRISMA guidelines, to investigate the evidence for associations between PARTICIPANTS/MATERIALS SETTING
methodsTwo independent reviewers performed title and abstract, then full-text screening, using inclusion/exclusion criteria decided MAIN RESULTS AND THE ROLE OF CHANCE: 3360 titles and abstracts were screened for inclusion, following the removal of duplicates, with 57 undergoing full text review and 26 eligible studies identified for inclusion (human = 4, animal-model = 22). The collated results show clear evidence of significant germ cell loss and disruption to other gonadal cell types in male and female animal-model gonadal tissues exposed both LIMITATIONS REASONS FOR CAUTION: The evidence provided was limited by the small number of studies available reporting on reproductive outcomes following WIDER IMPLICATIONS OF THE
findingsThis review provides evidence for the vulnerability of foetal gonads to cancer therapy agents and the potentially damaging effects of STUDY FUNDING/COMPETING INTERESTS: No specific funding was received for this study. R.T.M. is supported by a UK Research and Innovation (UKRI) Future Leaders Fellowship (Grant Reference: MR/Y011783/1). The authors declare that they have no conflicts of interest. REGISTRATION NUMBER: Study protocol-PROSPERO (RD42021272882 and CRD42021271892).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.