Evidence map›Paper›PMID 40843454›Full record

ArticleeGastroenterology2025

Blood microbial DNA signature differentiates hepatocellular carcinoma from metastatic lesions.

Caitlin Guccione, Ana Carolina Dantas Machado, Fady Youssef, Isabella Angeli-Pahim, Sergio Duarte, Curtis Warren, Sawyer Farmer, Gregory Humphrey, Roland Alexander Richter, Daniel McDonald and 7 more

Abstract read
In one paragraph

Article in eGastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Caitlin Guccione *Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Ana Carolina Dantas Machado *Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.
Fady YoussefDivision of Gastroenterology, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-1020-0869
Isabella Angeli-PahimDepartment of Surgery, University of Florida, Gainesville, Florida, USA.
Sergio DuarteDepartment of Surgery, University of Florida, Gainesville, Florida, USA.
Curtis WarrenDepartment of Surgery, University of Florida, Gainesville, Florida, USA.
Sawyer FarmerDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Gregory HumphreyDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Roland Alexander RichterDivision of Gastroenterology, University of California San Diego, La Jolla, California, USA.
Daniel McDonaldDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Yuhan WengBioinformatics and Systems Biology Program, University of California San Diego, La Jolla, California, USA.
Adam BurgoyneMoores Cancer Center, University of California San Diego, La Jolla, California, USA.
Rohit LoombaDivision of Gastroenterology, University of California San Diego, La Jolla, California, USA.
Kit CurtiusDivision of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-2678-0960
Ali ZarrinparDepartment of Surgery, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-6812-1816
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Amir ZarrinparDivision of Gastroenterology, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-6423-5982

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Tissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2020 to 2024
$12.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
HIV MASLD Clinical Research Network (HCRN)R01DK121378 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, ROHIT LOOMBA · 2020 to 2026
$8.7M
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunityDP1AT010885 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KNIGHT, ROB · 2019 to 2023
$5.5M
Bacterial biosensors for the prevention of gastrointestinal cancersR01CA241728 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEFF M HASTY, ROB KNIGHT · 2020 to 2026
$4.2M
The Role of Altered Luminal Dynamics in OSA-Induced AtherosclerosisR01HL148801 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZARRINPAR, AMIR · 2019 to 2023
$4.0M
BLRD VA I01 BX005707NCATS NIH HHS UH2 TR002087NCATS NIH HHS UH3 TR002087NCATS NIH HHS UL1 TR001442NCCIH NIH HHS DP1 AT010885NCI NIH HHS P30 CA014195NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA241728NCI NIH HHS R01 CA270235NCI NIH HHS R21 CA259921NCI NIH HHS U01 CA265719NCI NIH HHS U24 CA248454NHLBI NIH HHS P01 HL147835NHLBI NIH HHS R01 HL148801NIAAA NIH HHS P50 AA011999NIAID NIH HHS R01 AI163483NIBIB NIH HHS R01 EB030134NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK121378NIDDK NIH HHS R01 DK124318NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK130190
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, HepatocellularCell-Free Nucleic AcidsColorectal NeoplasmsDigestive System NeoplasmsGastrointestinal CancerLiver NeoplasmsMicrobiotaNeoplasm Metastasis

Identifiers

PMID40843454
PMCPMC12366555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.