ReviewFrontiers in bioengineering and biotechnology2025
Engineering copper and copper-based materials for a post-antibiotic era.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Biochemical Modulation of FeChemistry & biodiversity · 2026Article
- Targeting Ferroptosis and Cuproptosis for Antimicrobial Control in Postharvest Preservation.Comprehensive reviews in food science and food safety · 2026Review
- Printing to Fight Antimicrobial Resistance Through Nano/Microstructured Platforms.Chemical record (New York, N.Y.) · 2026Review
- Antiviral Potential of Green-Synthesized Zinc Oxide and Copper Oxide Nanoparticles: Integrated In Vitro and In Silico Study.Nanomaterials (Basel, Switzerland) · 2026Article
- Copper/Copper Oxide Nanoparticles: Biological Synthesis, Characterization and Potential Biomedical Applications: Advances and Perspectives.Pharmaceuticals (Basel, Switzerland) · 2026Review
- A Therapeutic Copper Hydrogel for Seborrheic Dermatitis: From Fungal Eradication to Skin Lesion Repair.Advanced healthcare materials · 2026Article
- A broad-spectrum inhibitor of copper-exporting PProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Metal Oxide Nanocomposites as Next-Generation Antimicrobial Agents Against Oral Cariogenic Pathogens: Mechanistic Actions of Ag-ZnO and Cu-ZnO onMaterials (Basel, Switzerland) · 2026Article
- Synergistic effect of copper(ii) ions and orthosilicate group in nanosized hydroxyapatite.RSC advances · 2026Article
- Surface Oxide Film and Antibacterial Activity of Zirconium-Based Bulk Metallic Glasses.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Eco-friendly optimization and green biosynthesis of Cu(II) nanocomposites from Stereum ostrea biomass extract: enhanced antibiofilm efficacy against pathogenic bacteria.Discover nano · 2026Article
- Copper doped hybrid nanosponges functionalized with Aplysina aerophoba extract for enhanced bioactive performance.Scientific reports · 2026Article
- A First-In-Class Broad Spectrum Inhibitor of Copper Exporting PbioRxiv : the preprint server for biology · 2026Article
- Staphylococcus aureus periprosthetic joint infection and its pathogenesis in total hip and knee arthroplasty: a narrative review.EFORT open reviews · 2026Review
- Biodegradable Antibacterial Nanostructured Coatings on Polypropylene Substrates for Reduction in Hospital Infections from High-Touch Surfaces.Nanomaterials (Basel, Switzerland) · 2026Article
- Different forms of cardiomyocyte death in post-myocardial infarction ventricular remodeling: mechanisms and therapeutic strategies.Frontiers in cardiovascular medicine · 2026Review
- Antibacterial activity and cytocompatibility of Cu-coated PETG for clear aligner applications.Frontiers in bioengineering and biotechnology · 2026Article
- Photocatalytic performance of CuI/Cu2+ -TiO2 for controlling Magnaporthe oryzae infection in rice plants.PloS one · 2026Article
- Antimicrobial Activity and Characterization of a Validated Copper-Complexed Polymer Tape for Surface Disinfectant Applications.Antibiotics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the emergence of multidrug-resistant bacteria and the frequent outbreaks of novel viral pathogens have intensified the demand for novel, efficient, and low-toxicity antimicrobial materials. Copper and copper-based materials, owing to their broad-spectrum and potent antimicrobial properties, have attracted increasing attention across diverse fields, including medicine, agriculture, and environmental science. This review provides a comprehensive overview of the development history, antimicrobial and antiviral mechanisms, fabrication techniques, and bioactive characteristics of copper and its derivatives. It further highlights their current applications in healthcare, public infrastructure, food processing, textiles, and modern agriculture. Challenges associated with material stability, cytotoxicity and environmental safety, are critically discussed. Finally, future perspectives are proposed, emphasizing advances in material synthesis, the development of stable nano-coatings, controlled release strategies, low-toxicity and low-resistance formulations, establishment of standardized pharmacological and toxicological evaluation systems, drug delivery applications, and copper pollution control. This review aims to inform future efforts in overcoming the current limitations of copper-based antimicrobials and supporting their potential future integration into applications across medicine, public health, environmental protection, and agricultural innovation, contingent upon resolving current translational and regulatory challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.