Evidence map›Paper›PMID 40843377›Full record

ArticleFrontiers in pharmacology2025

Ethnopharmacological exploration and isolation of HIV-1 latency-reversing agents from Sudanese medicinal plants.

Khaled M Elamin, Naoki Kishimoto, Teppei Kawahara, Sara Mustafa Idris Elbashir, Tae Yasutake, Mikiyo Wada, Yuki Hitora, Maha Kordofani, Wadah Osman, Mustafa Idris Elbashir and 1 more

Abstract read
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In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Traditional Medicine Extracts ofInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khaled M Elamin *Global Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Naoki Kishimoto *Global Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Teppei KawaharaGlobal Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Sara Mustafa Idris ElbashirGlobal Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Tae YasutakeDepartment of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Mikiyo WadaGlobal Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yuki HitoraDepartment of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Maha KordofaniDepartment of Botany, Faculty of Science, University of Khartoum, Khartoum, Sudan.
Wadah OsmanDepartment of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia.
Mustafa Idris ElbashirDepartment of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Shogo MisumiGlobal Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1 infection remains a major health challenge, especially in resource-limited settings such as Sudan, where traditional medicine is widely practiced for managing infectious diseases, including HIV/AIDS. In this study, we selected ten Sudanese medicinal plants traditionally used to treat immune-related and infectious diseases. The selection was based on ethnobotanical reports and local knowledge of HIV/AIDS-related treatments. Crude extracts were prepared using either absolute methanol or 50% ethanol via maceration, resulting in a total of 20 extracts. The extracts were then screened for HIV-1 latency reversal using a luciferase reporter assay in TZM-bl cells. The 50% ethanolic extract of

Indexed as

anti-HIV drugsHIV-1/AIDSlatency-reversing agentsSudanese medicinal plantsSudanese traditional healers

Identifiers

PMID40843377
PMCPMC12366430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.