Evidence map›Paper›PMID 40843363›Full record

ArticleACS medicinal chemistry letters2025

Pharmacokinetic and Biodistribution Studies of [

Luke N Jaskowski, Nicholas A Clanton, Nancy J Wilkinson, Jennifer L Bartels, Peter M LoCoco, Amber N Frantz, Andrew D Boyer, Joseph W Boerma, Jycole E M Bush, Seth D Brown and 7 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luke N JaskowskiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Nicholas A ClantonVoelcker Preclinical Pharmacology Core, University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID https://orcid.org/0000-0001-5936-4878
Nancy J WilkinsonDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, United States.
Jennifer L BartelsDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.ORCID https://orcid.org/0000-0002-0137-2397
Peter M LoCocoVoelcker Preclinical Pharmacology Core, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Amber N FrantzVoelcker Preclinical Pharmacology Core, University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID https://orcid.org/0009-0001-7185-8894
Andrew D BoyerVoelcker Preclinical Pharmacology Core, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Joseph W BoermaVoelcker Preclinical Pharmacology Core, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Jycole E M BushDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, United States.
Seth D BrownDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Kayylen FernandezDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Noel E ArcherDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Volkan TekinDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Solana R FernandezDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
April L RisingerDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, United States.ORCID https://orcid.org/0000-0002-4363-3268
Doug E FrantzVoelcker Preclinical Pharmacology Core, University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID https://orcid.org/0000-0002-4509-4579
Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.ORCID https://orcid.org/0000-0003-0090-0191

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Optimization of a novel class of microtubule stabilizersR01CA219948 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RISINGER, APRIL L · 2018 to 2022
$1.7M
NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA219948
6 · The paper itself

Abstract

The taccalonolides are plant-derived microtubule stabilizers that covalently and specifically bind β-tubulin and provide antitumor efficacy in drug-resistant tumor models both in vitro and in vivo. Herein, we report the radiolabeling, in vitro uptake, and in vivo imaging of a

Indexed as

microtubule stabilizersPET imagingpharmacokineticstriple-negative breast cancer

Identifiers

PMID40843363
PMCPMC12366129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.