Evidence map›Paper›PMID 40843343›Full record

ArticlePatterns (New York, N.Y.)2025

HistoChat: Instruction-tuning multimodal vision language assistant for colorectal histopathology on limited data.

Usman Afzaal, Ziyu Su, Usama Sajjad, Thomas Stack, Hao Lu, Shuo Niu, Abdul Rehman Akbar, Metin Nafi Gurcan, Muhammad Khalid Khan Niazi

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Usman AfzaalDepartment of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ziyu SuDepartment of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Usama SajjadDepartment of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Thomas StackEdward Via College of Osteopathic Medicine, Blacksburg, VA, USA.
Hao LuCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Shuo NiuDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Abdul Rehman AkbarDepartment of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Metin Nafi GurcanCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Muhammad Khalid Khan NiaziDepartment of Pathology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Funding

An ensemble deep learning model for tumor bud detection and risk stratification in colorectal carcinoma.R01CA276301 · NCI · OHIO STATE UNIVERSITY · PI Wei Chen, Muhammad Khalid Khan Niazi · 2023 to 2026
$2.0M
NCI NIH HHS R01 CA276301
6 · The paper itself

Abstract

Artificial intelligence (AI) has the potential to greatly enhance diagnostic pathology, including the analysis of tissue samples to detect diseases such as colorectal cancer. This study explores how large language models (LLMs) and multimodal LLMs (MLLMs) can improve histopathological analysis by using medical data to aid diagnostics. However, challenges such as data quality and availability limit their effectiveness. To address these challenges, we introduce HistoChat, an AI-powered assistant designed to assist in colorectal cancer histopathology. It uses advanced techniques to improve data quality, such as generating image combinations and question-answer (QA) pairs to boost its learning. Despite working with limited data, HistoChat has significantly improved key metrics, including BLEU, ROUGE-L, and BERTScore, with an overall accuracy of 69.1% in human evaluation. These results suggest that HistoChat is a promising tool for enhancing diagnostic accuracy, especially in cases where data are scarce.

Indexed as

colorectal cancerdeep learningdiagnostic pathologyhistopathologyinstruction tuningmultimodal large language models

Identifiers

PMID40843343
PMCPMC12365532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.