ArticleFrontiers in neurology2025
Targeted temperature management in patients with acute basilar artery occlusion after successful recanalization.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: Targeted temperature management (TTM) has been reported to improve outcomes in retrospective clinical studies, especially after recanalization in patients with anterior circulation stroke. However, the efficacy of TTM in managing posterior circulation stroke remains unexplored. Therefore, we investigated the clinical effects of TTM in patients with acute basilar artery occlusion who had successful revascularization. Methods: We enrolled patients with acute ischemic stroke due to basilar artery occlusion, with an initial National Institutes of Health Stroke Scale score of ≥ 10, who had successful recanalization (defined as thrombolysis in cerebral ischemia grade ≥ 2b). All patients underwent a TTM protocol targeting a core temperature of 36°C, supported by mechanical ventilation and at least 24 h of temperature management. Clinical outcomes were compared, including favorable outcomes at 3 months (defined as a modified Rankin Scale score of ≤3), mortality, length of intensive care unit (ICU) stay, and safety profiles. Results: The TTM group ( Conclusion: TTM may not improve clinical outcomes in patients with acute basilar artery occlusion after successful recanalization.
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