Evidence map›Paper›PMID 40843211›Full record

ArticleNursing (Auckland, N.Z.)2025

A Brief Report of an Executive Functioning Training Pilot RCT in Adults with HIV: A Descriptive Case Comparison Study.

Ikenna Obasi Odii, Hathaichanok Phaowiriya, Shayla B Brooks, Nicholas K Wright, Andres Azuero, Pariya L Fazeli, Junghee Lee, Crystal Chapman Lambert, Dara L James, Emma Sophia Kay and 1 more

Abstract read
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In one paragraph

Article in Nursing (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ikenna Obasi OdiiSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0009-0004-2632-9215
Hathaichanok PhaowiriyaSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0009-0002-7282-0457
Shayla B BrooksSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0009-0006-7241-5477
Nicholas K WrightSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Andres AzueroSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-9883-1424
Pariya L FazeliSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-6629-0010
Junghee LeeDepartment of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-9567-8700
Crystal Chapman LambertSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5542-8176
Dara L JamesEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0002-0823-9185
Emma Sophia KaySchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-8425-9196
David Eugene VanceSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-0498-6263

Funding

Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults with HIVR21AG077957 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VANCE, DAVID E · 2022 to 2023
$408k
NIA NIH HHS R21 AG077957
6 · The paper itself

Abstract

Background and Purpose: Cognitive intra-individual variability (IIV) refers to the fluctuations observed in cognitive performance. The aim of this article was to characterize and describe for illustrative purposes an approach to administer executive functioning training to people living with HIV (PLWH) to reduce their cognitive IIV. This brief report highlights four cases in an on-going study investigating cognitive IIV in HIV. In HIV, cognitive IIV has been associated with cognitive decline, cortical atrophy, and mortality risk. The Executive Dysfunction Hypothesis suggests improving executive functioning could reduce cognitive IIV. Study Design: In the parent on-going pilot RCT (called the Executive Functioning Training (EFT) Study), 120 PLWH are randomized to either a no-contact control group or an executive functioning training group which receives 20 hours of computerized exercises. To characterize this study, this article describes an interim descriptive case analysis ( Results: Using the Connor's Continuous Performance Test 3 Conclusion: This finding suggests that by improving executive functioning through executive functioning training, this may stabilize cognitive functioning in general, as indicated by reduced cognitive IIV. Although preliminary, these encouraging results support the Executive Dysfunction Hypothesis and suggests further exploration of cognitive IIV may provide insights on how to improve cognition in aging PLWH. Implications for neuroscience nursing are provided.

Indexed as

cognitioncognitive variabilityexecutive dysfunctionexecutive functionHIV/AIDS

Identifiers

PMID40843211
PMCPMC12365781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.