ArticleFrontiers in nutrition2025
Lifestyle factors and hyperuricemia risk: a prospective cohort study of 14,635 participants examining the protective role of daily stair climbing.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- From Multidimensional Management to Mechanistic Insight: A Review of Interventions for Hyperuricemia.International journal of molecular sciences · 2026Review
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6 authors.
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Abstract
Background: This study aimed to explore the association between daily stair climbing and the risk of hyperuricemia and to investigate the potential mediating role of blood lipid biomarker levels in this association. Methods: This study is a prospective cohort study from the UK Biobank, including 14,635 participants. Participants were categorized based on their self-reported daily stair climbing habits and the presence of hyperuricemia, which was defined as serum uric acid concentration > 420 μmol/L for men and > 360 μmol/L for women. Blood lipid biomarker levels were assessed as potential mediators. We used a mediation analysis framework to estimate the direct and indirect effects of daily stair climbing on hyperuricemia risk. All analyses were conducted using R Studio version 4.2.3. Statistical significance was defined as a two-sided Results: Overall, compared to the no stair climbing group, with full adjustment, we observed a significant negative correlation between participants who climbed 160 to 200 steps of stairs daily and hyperuricemia; the HRs were 0.70 (95% CI: 0.51-0.95, Conclusion: Daily stair climbing is associated with a reduced risk of hyperuricemia, and this relationship may be partially mediated by alterations in high-density lipoprotein cholesterol and triglyceride levels. These findings suggest that promoting daily physical activity, such as stair climbing, may be an effective strategy for managing uric acid levels and reducing the risk of hyperuricemia.
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