ReviewFrontiers in cell and developmental biology2025
Invadosomes as "shape-shifters" of cellular maturation: insights from megakaryocytes.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Invadosomes are a family of subcellular actin-based structures essential for cell-extracellular matrix (ECM) interaction and remodeling. In non-invasive cells, they are referred to as podosomes, which enable adhesion, migration, and ECM remodeling via secretion of metalloproteinases or mechano-traction. In invasive tumoral cells, these structures are called invadopodia due to their function. Despite structural similarity, podosomes appear as highly regular dots in 2D and do not always exhibit ECM-degradative abilities; hence, the term "degradative dot-podosomes" is used in this paper. Invadopodia are consistently degradative, fewer in number, slightly larger, deeper, less regular-shaped, and longer-lived. In tumor cells, collagen I induces the formation of linear invadosomes, which promote invasion by degrading collagen through the action of MT1-MMP (
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