ReviewMedComm2025
Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions.
Review in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Determination of selected heavy metals in soil and their impact onToxicology reports · 2026Article
- Integrated Phytoremediation and Microbial Mitigation Strategies for Sustainable Restoration of Toxic Metal-Contaminated Soils.Biology · 2026Review
- Future Outlook Toward Heavy-Metal-Free Metal Chalcogenide Nanocrystals for Optoelectronic Applications.Small science · 2026Review
- Assessment of Potentially Toxic and Essential Metals in Commonly Consumed Tomato Ketchup Brands from Local Markets in Faisalabad, Pakistan, and Associated Health Risks.Biological trace element research · 2026Article
- Heavy Metals, Trace Elements, and Smoking Biomarkers in Venous and Cupping Blood Before and After Wet Cupping Therapy.Biological trace element research · 2026Article
- Review
- Review
- Dietary and Environmental Exposure to Toxic Elements in Endometriosis: A Missing Piece of the Etiological Puzzle?Nutrients · 2026Review
- Potentially Toxic Elements-mediated Toxicity on Vagus Nerve and Cellular Energy Expenditure in Noncommunicable Diseases: A Systematic Review and Evidence Map.Biological trace element research · 2026Review
- Mitochondrial Toxicology of Heavy Metals and Pesticides: Transport Systems, Mitochondrial Dysfunction and Permeability Transition.International journal of molecular sciences · 2026Review
- Potential Toxic Elements in Farm Soils and Vegetables of Northern Bangladesh: Impact on Soil Health and Human Safety.Journal of xenobiotics · 2026Article
- A Multidisciplinary Review of Phytoremediation Strategies for Heavy Metal-Contaminated African Soils: From Geochemical Assessment to Genetic Enhancement.Journal of xenobiotics · 2026Review
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Nutrient-Driven Modulation of Microbial, Plant, and Rhizosphere Processes for Heavy Metal Remediation.Plants (Basel, Switzerland) · 2026Review
- Unravelling Mechanisms of Oxinflammation Induced by Heavy Metals.Metabolites · 2026Review
- Hybrid Bi/AuNP-enabled laser-induced graphene sensor for flexible and simultaneous detection of Zn²⁺ and Cd²⁺ in seawater and soil samples.Mikrochimica acta · 2026Article
- Genetic Polymorphisms as Modifiers of Health Risks from Exposure to Toxic Elements: A Traditional Literature Review.Toxics · 2026Review
- Metallomic Analysis of Vitreous Humor of the Human Eye-A Post-Mortem Multielemental Study.International journal of molecular sciences · 2026Article
- Role of cuproptosis in digestive system tumors (Review).International journal of molecular medicine · 2026Review
- Toward Smart Salivary Diagnostics: A Comprehensive Review of Heavy Metal Biomarkers and Digital Risk Modeling.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metals (HMs), such as chromium, arsenic, cadmium, mercury, and lead, constitute a class of environmental pollutants with significant toxicity that pose a serious threat to human health. This review provides a comprehensive overview of the biochemical properties of HMs, and their effects at the cellular, molecular, and genetic levels. HMs exert their toxic effects by interfering with various intracellular biochemical processes, including enzyme activity, protein synthesis, and energy metabolism. Furthermore, they can disrupt the integrity of cell membranes and affect cellular signaling, leading to cellular dysfunction and death. At the molecular and genetic levels, HMs can cause DNA damage and induce gene mutations, thereby affecting genetic transmission and expression. Then, the effects of HMs on the nervous system, kidneys, cardiovascular system, reproduction, and cancer risk are discussed. Therapeutic strategies, such as chelation therapy, antioxidants and free radical scavengers, supportive therapy, and prevention and reduction of exposure, have been shown to mitigate the toxic effects of HMs. Last, based on the current findings on the mechanisms of HMs, future research directions are prospected. Through multidisciplinary cooperation and integrated interventions, it is expected that the health risks posed by HMs can be alleviated. Future research needs to further elucidate the mechanisms of HMs toxicity, develop more effective treatments, and strengthen preventive and control measures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.