ArticleJournal of dental research, dental clinics, dental prospects2025
Platelet-rich fibrin and concentrated growth factor in the treatment of immediate implants in teeth with periapical lesions: A clinical trial with two-year follow-up.
Article in Journal of dental research, dental clinics, dental prospects, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Concentrated growth factor in oral bone regeneration: A narrative review.Regenerative therapy · 2026Review
- Immediate implant placement in infected extraction sockets: A scoping review of case selection, decontamination protocols, clinical outcomes and complications.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Safety and feasibility of immediate implant placement in diabetic patients: A systematic review and meta-analysis.Biomedical reports · 2026Article
- PRF-Modified Graft Materials in Lateral Sinus Augmentation: A Systematic Review of Histologic Outcome.Biomedicines · 2026Review
- Osteo-Inductive Strategies for Enhancing Osseointegration and Optimizing Peri-Implant Emergence Profile: A Narrative Review.Dentistry journal · 2026Review
- Socket preservation with and without lovastatin in combination with synthetic bone graft substitute: A double-blind clinical trial.Journal of advanced periodontology & implant dentistry · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study was designed to compare the effect of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on the immediate implants placed in previously infected sites. Methods: A total of 210 patients were included in this randomized clinical trial. The remaining tooth was extracted, and the periapical lesion was removed. Then, PRF and CGF were placed in the socket in the PRF and CGF groups, respectively. No intervention was performed in the control group. The implant was inserted and sutured. Postoperative pain was measured using VAS. Plaque index (PI), bleeding on probing (BOP), buccal and proximal gingival esthetic index (GEI-B and GEI-P), crestal bone level, periapical lesion size, and Implant Health Scale (IHS) were evaluated. Data were analyzed with SPSS 18 using one-way ANOVA, Tukey, and repeated measures test at 0.05 significance level. Results: The mean BOP and pain in each period were significantly higher in the control group than in the PRF and CGF groups and in the PRF group than in the CGF group ( Conclusion: PRF and CGF guaranteed the successful osseointegration of immediate implants in previously infected sites. CGF and PRF positively affected the soft tissue and hard tissue around the immediate implants. CGF had more promising effects than PRF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.