Evidence map›Paper›PMID 40843102›Full record

ArticleClinical case reports2025

Foreign Body Granuloma After Polylactic Acid Filler Injection for Penile Girth Enhancement: Three Cases Report.

Mykola Boiko, Oleksandr Boiko, Serhiy Pasyechnikov, Mykola Notsek

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mykola BoikoClinic "Androcentr" Kyiv Ukraine.
Oleksandr BoikoUniversity Hospital of Cruces Barakaldo Spain.ORCID https://orcid.org/0000-0002-5586-0337
Serhiy PasyechnikovO.O. Bogomolets National Medical University Kyiv Ukraine.
Mykola NotsekClinic "Androcentr" Kyiv Ukraine.ORCID https://orcid.org/0000-0003-0861-304X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile girth enhancement is achieved using a variety of fillers, including autologous fat injection, silicone, collagen, hyaluronic acid, polylactic acid (PLA), polymethylmethacrylate, and dextran. While PLA has a good filling effect due to its bio-stimulatory properties, it may cause complications in a certain percentage of cases. We describe three patients who developed granulomatous reactions at least 2 months after receiving subcutaneous injections of PLA-based fillers. In two of the three cases, surgical removal of the infiltrate was necessary due to insufficient response to conservative treatment. Histological examination revealed unspecific chronic granulomatous inflammation of soft tissues. Based on these cases, we conclude that the causes of granuloma formation and ways to prevent it still require further research. Aesthetic specialists should carefully select patients, materials, and application techniques. Patients should be informed about the possible complications of penile girth enhancement.

Indexed as

dermal fillersforeign body granulomahyaluronic acidinjectionspenispolylactic acid

Identifiers

PMID40843102
PMCPMC12364716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.