Evidence map›Paper›PMID 40843039›Full record

ArticleOxford medical case reports2025

Severe cardiopulmonary complications of ketamine: Acute pulmonary Edema in a cardiac patient.

Tahir Shahzad, Zain A Bhutta, Muhammad Abd Ur Rehman

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tahir ShahzadDepartment of Emergency Medicine, Hamad Medical Corporation, Al Rayyan Road, Doha 3050, Qatar.ORCID https://orcid.org/0000-0001-7846-2828
Zain A BhuttaDepartment of Emergency Medicine, Hamad Medical Corporation, Al Rayyan Road, Doha 3050, Qatar.ORCID https://orcid.org/0000-0003-4269-5077
Muhammad Abd Ur RehmanDepartment of Emergency Medicine, Hamad Medical Corporation, Al Rayyan Road, Doha 3050, Qatar.ORCID https://orcid.org/0000-0002-2566-3826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketamine use in the emergency department is more widespread than ever due to its favorable safety profile and combined analgesic and anesthetic properties. Its ability to stimulate the cardiovascular system via the sympathetic nervous system is particularly important, as patients can develop hemodynamic instability. However, concerns remain regarding the risk of decompensated cardiac function due to extreme tachycardia and severely elevated systemic blood pressure. In this case, a middle-aged male with a known history of coronary artery disease and congestive heart failure deteriorated significantly after ketamine was administered for sedation to facilitate a computed tomography pulmonary angiogram. He developed acute pulmonary edema and cardiogenic shock, requiring mechanical ventilation and inotropic support. Therefore, it is advisable to use ketamine with caution in patients with underlying heart failure. Further research is needed to establish a causal relationship between ketamine and cardiac decompensation leading to cardiogenic shock and pulmonary edema in selected patients.

Indexed as

Acute pulmonary edemacardiogenic shockketamineprocedural sedation

Identifiers

PMID40843039
PMCPMC12365973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.