Evidence map›Paper›PMID 40843038›Full record

ArticleOxford medical case reports2025

Fatal facial necrotizing fasciitis: a case report highlighting diagnostic and therapeutic challenges.

Muhammad Sheraz Hameed, Syed Rafay Hussain Zaidi, Ali Iqbal, Muhammad Ahsan, Austin Mitchell, Azka Asad Mirza, Joshiah Gordon, Rahmat Gul Omarzai

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammad Sheraz HameedDepartment of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Syed Rafay Hussain ZaidiDepartment of Medicine, Uc-Health Parkview Medical Center, Pubelo,USA.
Ali IqbalDepartment of Medicine, Thomas Jefferson University Hospital, Philadelphia, USA.
Muhammad AhsanDepartment of Medicine, Federal Medical and Dental College, Islamabad, Pakistan.
Austin MitchellDepartment of Medicine, Uc-Health Parkview Medical Center, Pubelo,USA.
Azka Asad MirzaDepartment of Medicine, Al-Nafees Medical College (Isra University), Islambad, Pakistan.
Joshiah GordonDepartment of Medicine, Uc-Health Parkview Medical Center, Pubelo,USA.
Rahmat Gul OmarzaiDepartment of Medicine, Nangarhar Medical University, Jalalabad, Afghanistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Facial Necrotizing Fasciitis (FNF) is a rare but aggressive, life-threatening infection involving the face's subcutaneous tissues and underlying musculature. It can rapidly progress to septic shock and multi-organ failure if not promptly recognized and treated. The clinical course, including severe pain, disproportionate tenderness, and systemic signs, is often the most crucial factor in diagnosis. While computed tomography (CT) can aid in identifying early signs such as soft tissue swelling and gas formation, clinical suspicion remains paramount and should not be delayed by reliance on imaging alone. Without early intervention, FNF may lead to devastating outcomes, including disfigurement, blindness, or death. Case Presentation: We present the case of a 70-year-old male who developed facial necrotizing fasciitis with rapid systemic progression. He initially presented to the emergency department with acute tenderness and swelling of the right ear. CT imaging revealed extensive edema and swelling in the subcutaneous fat of the face, scalp, and neck, most prominently involving the right external ear. Despite aggressive supportive measures-including ventilatory, cardiovascular, and renal support-the infection progressed to severe multi-organ failure, ultimately resulting in death. Conclusion: This case highlights the fulminant course and high mortality risk associated with FNF. Early recognition based on clinical evaluation, supported-but not replaced-by imaging, is essential for diagnosis. Prompt intervention with broad-spectrum antibiotics and surgical debridement offers the best chance to improve outcomes and prevent catastrophic complications such as septic shock, multi-organ failure, and death.

Indexed as

FaceFasciitisMultiple Organ FailureNecrotizingSepsisSoft Tissue Infections

Identifiers

PMID40843038
PMCPMC12365970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.