Evidence map›Paper›PMID 40843023›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Maximum-entropy and subspace methods for high-resolution relaxation-diffusion distribution estimation.

Lipeng Ning

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Lipeng NingBrigham and Women's Hospital, Boston, MA, United States.ORCID https://orcid.org/0000-0003-4992-459X

Funding

Next generation in-vivo diffusion imaging at submillimeter resolutionR01MH116173 · NIMH · STANFORD UNIVERSITY · PI Yogesh Rathi, Kawin Setsompop · 2018 to 2026
$6.2M
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
Mapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curationR01MH132610 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2023 to 2025
$2.6M
Precision TMS with integrated visualization and analysis of real-time E-field and EEG source imagingR01MH136160 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Lipeng Ning · 2025 to 2026
$1.6M
Joint structural-and-functional MRI analysis for predicting electroconvulsive therapy response in major depressive disorderK01MH117346 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI NING, LIPENG · 2019 to 2023
$916k
Real-time visualization and precision targeting in transcranial magnetic stimulationR21MH126396 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI NING, LIPENG · 2021 to 2022
$493k
NIMH NIH HHS K01 MH117346NIMH NIH HHS R01 MH116173NIMH NIH HHS R01 MH125860NIMH NIH HHS R01 MH132610NIMH NIH HHS R01 MH136160NIMH NIH HHS R21 MH126396
6 · The paper itself

Abstract

Relaxation-diffusion distribution characterizes tissue microstructure using multi-contrast MRI data without using a multi-compartment model. This work applies and generalizes two nonlinear spectral estimation algorithms to compute relaxation-diffusion distributions and compares their performances with the standard linear inverse method. The first algorithm employs maximum entropy (MaxEnt) estimation, extending previous methods by incorporating measurement noise for improved robustness. The second algorithm is based on the MUltiple SIgnal Classification (MUSIC) subspace spectral estimation technique, enabling pseudo-spectral estimation of multi-exponential signals sampled on regular grids without solving optimization problems. Both methods were compared against the basis representation technique and the nonnegative least squares (NNLS) method using synthetic and

Indexed as

diffusion MRIdiffusion-relaxation distributionmaximum entropyquantitative relaxometrysubspace

Identifiers

PMID40843023
PMCPMC12365690

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.