Evidence map›Paper›PMID 40842956›Full record

ArticleJournal of toxicology2025

Early-Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High-Fat Diets.

Fubin Chen, Huihong Zhang, Haiyan Huang, Jianjun Liu, Wei Zhu, Lingeng Lu, Yirong Xie, Hongya Li, Shurong Pi, Jingyi Zhong and 5 more

Abstract read
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In one paragraph

Article in Journal of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fubin ChenDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Huihong ZhangFood Safety and Health Research Center, Guangdong-Hongkong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Haiyan HuangShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, China.
Jianjun LiuShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, China.
Wei ZhuGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, Guangdong, China.ORCID https://orcid.org/0000-0001-5796-4167
Lingeng LuDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven 06510, Connecticut, USA.ORCID https://orcid.org/0000-0001-9871-0809
Yirong XieDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Hongya LiDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Shurong PiDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Jingyi ZhongDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Shuren DingDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Ke ZhangFood Safety and Health Research Center, Guangdong-Hongkong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Fan WuFood Safety and Health Research Center, Guangdong-Hongkong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Bo ZhangFood Safety and Health Research Center, Guangdong-Hongkong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.ORCID https://orcid.org/0000-0003-1208-5489
Yun HeDepartment of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.ORCID https://orcid.org/0000-0001-7263-3243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have identified early life as a sensitive window for BPA exposure that may increase the risk of metabolic disease in adulthood. However, less attention has been paid to the effects of early-life BPA exposure on the pancreas and its relationship to the development of metabolic diseases. In this study, we exposed females to 50 μg/kg/d BPA in drinking water from 6 days of gestation to weaning of offspring mice and administered a high-fat diet after weaning of offspring mice. We found that early-life BPA-exposed male mice gained body weight, had downregulated pancreatic

Indexed as

bisphenol Aearly-life exposurehigh-fat dietlipidomicspancreatic damage

Identifiers

PMID40842956
PMCPMC12367390

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.