ReviewInternational journal of preventive medicine2025
The Prevalence of Stevens-Johnson Syndrome Complications due to Antiepileptic Drug Use: A Systematic Review and Meta-Analysis.
Review in International journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Real-World Data on Severe Cutaneous Adverse Reactions to Drugs.Pharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Stevens-Johnson syndrome (SJS) as a dermatological emergency, is a severe condition with a 5% mortality rate. Antiepileptic drugs (AEDs) are linked to an increased risk of SJS, but the magnitude of this risk varies between studies, so comprehensive investigations are needed to evaluate the prevalence of SJS complications associated with AEDs. Methods: Based on PRISMA guidelines, Online databases including PubMed/Medline, CINAHL (EBSCO), Web of Science (ISI), Scopus, and Embase were searched using related MeSH-term. Studies reporting SJS as a complication of AEDs or considering AEDs suspected of inducing SJS were included. The Studies which not published in English mentioned other complications instead of skin manifestations were excluded. The data was analyzed using the STATA 14 software. To investigate heterogeneity, the Q Cochrane test and I Results: Of 1630 studies, 24 studies were included in meta-analysis. The overall pooled prevalence of SJS was 23.22% (95% CI: 17.32-29.11). The pooled prevalence of SJS was 22.56% (95% CI: 16.55-28.57) in the Retrospective Cohort; 30.90% (95% CI: 5.32-56.48) in perspective Cohort, 24.84% (95% CI: 18.02-31.67) in Asia, 11.20% (95% CI: 6.10-18.4) in America, and 11.70% (95% CI: 2.77-20.63) in Europe. The I Conclusions: Clinicians should be cautious when prescribing AEDs, especially to high-risk populations. More research is needed to understand SJS mechanisms and identify genetic markers for personalized treatment approaches.
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