Evidence map›Paper›PMID 40842868›Full record

ReviewNational science review2025

The coming era of proteomics-driven precision medicine.

Ying Jiang, Jian Wang, Aihua Sun, Hongxing Zhang, Xiaobo Yu, Weijie Qin, Wantao Ying, Yanchang Li, Cheng Chang, Xiaowen Wang and 12 more

Abstract readReview
In one paragraph

Review in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Proteomic analysis of rose apple reveals defense proteins activated during Lasiodiplodia theobromae infection.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Neuroproteomic Profiling of the Anxiolytic Potential ofInternational journal of molecular sciences · 2026
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Ying JiangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Jian WangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Aihua SunState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Hongxing ZhangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Xiaobo YuState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Weijie QinState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Wantao YingState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Yanchang LiState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Cheng ChangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Xiaowen WangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Linhai XieState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Wei LiuAcademy of Military Medical Sciences, Beijing 100039, China.
Jialin LiuState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Xiaomei ZhangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Qunjiao YanAcademy of Military Medical Sciences, Beijing 100039, China.
Yu ZouState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Chuanping ZhaoState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Haofan SunState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.ORCID https://orcid.org/0000-0002-4335-7371
Jian ZhangState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.
Shicheng SuState Key Laboratory of Medical Proteomics, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-2280-3587
Qiang GaoKey Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Fuchu HeState Key Laboratory of Medical Proteomics, Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Academy of Military Medical Sciences, Beijing 102206, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of 'proteomics-driven precision medicine' highlighted in 2019 emphasized the potential of proteomics to transform precision medicine by offering deeper insights into dynamic biological processes. Since then, this field has seen remarkable advancements, interlinking with key pillars such as protein expression profiling, post-translational modifications, protein-protein interactions and spatial proteomics to transform healthcare. Technological progress has led to the creation of comprehensive reference maps of proteomes, identification of over 90% of human protein-coding genes, and detailed cellular and molecular landscapes within organs. Proteomics has significantly advanced health monitoring and disease surveillance by developing aging models, predicting disease risks with superior protein risk scores, identifying biomarkers for early conditions like dementia, and securing Food and Drug Administration (FDA) approval for multiple cancer biomarkers. By providing deeper insights into the proteome's complexity and dynamics, proteomics is revolutionizing our understanding, diagnosis and treatment of diseases, firmly establishing itself as a cornerstone of precision medicine.

Indexed as

phronesis medicinepost-translational modificationsprecision medicineprotein–protein interactionsproteomicsspatial proteome

Identifiers

PMID40842868
PMCPMC12365760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.