ArticleFrontiers in microbiology2025
Protein functional domain analysis enhances genotype-phenotype associations in comparative genomic studies of
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: The genomes of 40 strains of Results: The majority of our findings regarding phenotypic adaptation over time were consistent with the population structure and followed the evolutionary pathways described in the literature. However, an exact relationship between the presence of genes and specific phenotypes could not be established. The SAPP approach enabled the identification of 189 protein domains that were significantly enriched in antibiotic-resistant strains, as well as 87 domains associated with other phenotypic adaptations. In some cases, the domains were commonly associated with antibiotic resistances, for example, outer membrane efflux pumps and porins. However, we also detected a number of domains with unknown function. Discussion: Our findings provide a foundation for a more comprehensive understanding of the phenotypic adaptations occurring during microevolution in lung environments and facilitate the identification of new targets for the design of novel antimicrobial agents.
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