ArticleCureus2025
Type 1 Cryoglobulinemic Glomerulonephritis With IgG2-Kappa Arising From Monoclonal Gammopathy of Undetermined Significance: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This case report describes a rare presentation of Type 1 Cryoglobulinemic Glomerulonephritis due to IgG2 kappa monoclonal gammopathy in a 74-year-old man with a history of Monoclonal Gammopathy of Undetermined Significance (MGUS), classifiable under Monoclonal Gammopathy of Renal Significance (MGRS). The patient presented with acute kidney injury, hypertensive urgency, and a migratory rash. Kidney biopsy revealed glomerulitis with IgG2-kappa deposition. Pseudothrombi of IgG2-kappa paraprotein were also present within glomerular capillary and arteriolar lumens, accompanied by vasculitis. Although initial outpatient management focused on MGUS, rapid disease progression necessitated aggressive therapy, including high-dose corticosteroids, plasmapheresis, and hemodialysis. The patient's renal function improved following treatment, emphasizing the need for early recognition and timely intervention in cryoglobulinemia-related kidney disease. This case highlights the importance of kidney biopsy in diagnosing MGRS and underscores the role of targeted therapies in complex cases, particularly clone-directed treatment following initial clinical stabilization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.