Evidence map›Paper›PMID 40842776›Full record

ReviewCureus2025

Nucleus Accumbens: A Therapeutic Target for Radiomodulation for the Treatment of Alcohol Use Disorder.

Roshan Amurthur, Neelan J Marianayagam, David J Park, Steven D Chang, M Bret Schneider, John Adler

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roshan AmurthurScience, The Harker School, San Jose, USA.
Neelan J MarianayagamNeurosurgery, Stanford University School of Medicine, Palo Alto, USA.
David J ParkNeurosurgery, Stanford University School of Medicine, Palo Alto, USA.
Steven D ChangNeurosurgery, Stanford University School of Medicine, Palo Alto, USA.
M Bret SchneiderRadiation Oncology, Zap Surgical Systems, Inc., San Carlos, USA.
John AdlerRadiation Oncology, Zap Surgical Systems, Inc., San Carlos, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite progress in pharmaceutical and behavioral treatments, alcohol use disorder (AUD) continues to have a high relapse rate. While deep brain stimulation (DBS) of the nucleus accumbens (NAc) has shown therapeutic promise, its invasive nature poses significant risks. Radiomodulation, the focal delivery of sub-ablative ionizing radiation, offers a non-invasive alternative for neuromodulating deep brain structures. However, optimal targeting, dosing, and rationale for radiomodulation in AUD have not been discussed. This paper analyzes the NAc as a candidate target for radiomodulation and proposes NAc radiomodulation as a novel, potentially transformative therapeutic approach for AUD that warrants further investigation.

Indexed as

addictionalcohol use disorderneuromodulationnucleus accumbensradiomodulation

Identifiers

PMID40842776
PMCPMC12364606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.