Evidence map›Paper›PMID 40842698›Full record

ArticleChemical science2025

A malondialdehyde-activated fluorescent probe reveals lysosomal dysfunction in atherosclerosis.

Xia Zhang, Guocheng Li, Yanhua Li, Na Li, Wei Pan, Bo Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xia ZhangCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China liyanhua@sdnu.edu.cn lina@sdnu.edu.cn panwei@sdnu.edu.cn.
Guocheng LiCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China liyanhua@sdnu.edu.cn lina@sdnu.edu.cn panwei@sdnu.edu.cn.
Yanhua LiCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China liyanhua@sdnu.edu.cn lina@sdnu.edu.cn panwei@sdnu.edu.cn.
Na LiCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China liyanhua@sdnu.edu.cn lina@sdnu.edu.cn panwei@sdnu.edu.cn.ORCID https://orcid.org/0000-0002-0392-6672
Wei PanCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China liyanhua@sdnu.edu.cn lina@sdnu.edu.cn panwei@sdnu.edu.cn.ORCID https://orcid.org/0000-0002-2281-8749
Bo TangCollege of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China liyanhua@sdnu.edu.cn lina@sdnu.edu.cn panwei@sdnu.edu.cn.ORCID https://orcid.org/0000-0002-8712-7025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysosomes, serving as the digestive centers in cells, play a crucial role in lipid metabolism, inflammatory regulation, and cellular homeostasis. The bidirectional vicious cycle between lysosomal dysfunction and oxidative stress synergistically promotes the occurrence, development and instability of atherosclerosis. Therefore, accurate assessment of lysosomal oxidative stress contributes to monitoring atherosclerosis progression and facilitating early diagnosis. Herein, we constructed a malondialdehyde-activated fluorescent probe (Lyso-Np-Hy) by combining naphthalimide dye with a hydrazine group to evaluate lysosomal oxidative stress in atherosclerosis. Lyso-Np-Hy possessed high specificity and sensitivity to malondialdehyde in living cells and showed excellent subcellular localization of lysosomes. Importantly, the probe could monitor the malondialdehyde levels in lysosomes at different stages of atherosclerosis. This study provides a novel chemical tool for evaluating lysosomal dysfunction and tracking the progression of atherosclerosis.

Identifiers

PMID40842698
PMCPMC12362466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.