Evidence map›Paper›PMID 40842629›Full record

ArticleFrontiers in genetics2025

Genomic trajectories of colorectal cancer with choroidal metastasis: longitudinal insights from tissue and liquid biopsy via next-generation sequencing.

Alessandro Ottaiano, Luisa Circelli, Carmine Picone, Monica Ianniello, Raffaella Ruggiero, Roberto Sirica, Mariachiara Santorsola, Anna Chiara Carratù, Nadia Petrillo, Gaetana Cerbone and 4 more

Abstract read
In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alessandro Ottaiano *Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Napoli, Italy.
Luisa Circelli *AMES, Centro Polidiagnostico Strumentale srl, Casalnuovo diNapoli, Italy.
Carmine PiconeIstituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Napoli, Italy.
Monica IannielloAMES, Centro Polidiagnostico Strumentale srl, Casalnuovo diNapoli, Italy.
Raffaella RuggieroAMES, Centro Polidiagnostico Strumentale srl, Casalnuovo diNapoli, Italy.
Roberto SiricaAMES, Centro Polidiagnostico Strumentale srl, Casalnuovo diNapoli, Italy.
Mariachiara SantorsolaIstituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Napoli, Italy.
Anna Chiara CarratùIstituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Napoli, Italy.
Nadia PetrilloAMES, Centro Polidiagnostico Strumentale srl, Casalnuovo diNapoli, Italy.
Gaetana CerboneDivision of Medical Genetics, "S.G. Moscati" Hospital, Avellino, Italy.
Francesco SabbatinoMedical Oncology, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy.
Massimiliano BerrettaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Guglielmo NastiIstituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Napoli, Italy.
Giovanni SavareseAMES, Centro Polidiagnostico Strumentale srl, Casalnuovo diNapoli, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related death, with metastases typically involving the liver, lungs, and peritoneum. Choroidal metastases are extremely rare. We report a case of metastatic CRC with choroidal involvement, characterized by longitudinal genomic profiling using the TruSight Oncology 500

Indexed as

choroidal metastasiscirculating tumour DNAcolorecal cancernext-generation sequencingtumour heterogeneity

Identifiers

PMID40842629
PMCPMC12364847

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.