ArticleFrontiers in medicine2025
Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted antifungal therapy. Case presentation: A 47-years-old immunocompetent female presented with progressive headache and left-sided hemiparesis. Neuroimaging identified a basal ganglia mass initially misdiagnosed as a neoplastic lesion. Interventions: Surgical resection under neuroelectrophysiological monitoring was combined with amphotericin B, flucytosine, and fluconazole. Outcomes: Complete lesion excision, symptom resolution, and mild memory deficits at 4-years follow-up. Lessons: Combined therapy is pivotal for CM with parenchymal involvement; early surgery may mitigate irreversible neurological sequelae.
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