SynthesisFrontiers in medicine2025
Global trends in recombinant human growth hormone for the treatment of idiopathic short stature: a bibliometric analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application and integration of deep learning in tumour radiomics: bibliometrics and visualisation analysis.Frontiers in artificial intelligence · 2026Pooled it
- Growth Hormone Treatment Response and Machine Learning-Based Prediction in Idiopathic GHD and ISS: Analysis of the Korean LG Growth Study.Clinical endocrinology · 2026Observational
- Population characteristics of children with short stature and construction of a predictive model for growth hormone treatment efficacy.Frontiers in medicine · 2026Article
- Three decades of recombinant human growth hormone research in children born small for gestational age: a bibliometric analysis (1996-2025).Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The treatment of idiopathic short stature (ISS) with recombinant human growth hormone (rhGH) has been a subject of extensive research. This study aims to perform a bibliometric analysis of publications related to rhGH treatment for ISS, identifying research hotspots, key publications, and international collaboration networks. Methods: A literature search was conducted on the Web of Science Core Collection, covering literature from 1991 to 2024. Bibliometric tools including CiteSpace, VOSviewer and "bibliometrix" package of R were used to analyze publication trends, authorship, institutional contributions, and citation networks. Keyword co-occurrence and burst detection were performed to identify emerging research topics. Results: This area of study had experienced significant growth and maturation over the past three decades, characterized by increasing interest and investment in research pertaining to rhGH interventions for ISS. The majority of research output was concentrated in China. Leading contributors to this body of work included the University of Ulsan. The most prolific academic journals in this field were the Conclusion: This bibliometric analysis highlights the progression of rhGH research for ISS, shifting from foundational studies to contemporary priorities such as tailored therapies and clinical outcomes. Future research should focus on advancing precision medicine and optimizing treatment protocols while addressing safety concerns and long-term effectiveness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.