ReviewFrontiers in cardiovascular medicine2025
Management of intracardiac thrombosis in newborns: a case series and a narrative review of the literature.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal intracardiac thrombosis (ICT) is an uncommon but increasingly recognized condition that impacts neonatal morbidity and mortality, especially in critically ill term and preterm infants. Management includes supportive care and pharmacological or surgical intervention. This study explores the challenges associated with ICT in neonates. Methods: We described the clinical presentation and multidisciplinary management of two cases of intracardiac thrombosis. We also reviewed literature from Medline and PubMed using MeSH terms ("intracardiac thrombosis" AND "newborn"). Case series: In the first case, a very early (day 1) atrial thrombosis was unusually attached at the fossa ovalis and floating between the right and left atrium in an early-term newborn with meconium-aspiration syndrome and fetal inflammatory response syndrome. In the second case, a late-preterm neonate developed a left atrial thrombus after resuscitation at birth, with severe anemia (hemoglobin 5 g/dl) requiring two blood transfusions. In both cases, treatment with low-molecular-weight heparin resolved the thrombus without complications. Results: Critically ill term and preterm neonates should be carefully monitored due to the increased risk of thromboembolic events. The timing and decision to treat ICTs remain challenging. Supportive therapy is always indicated, including treatment of conditions such as sepsis, dehydration, anemia, and coagulopathy. Anticoagulant therapy with low-molecular-weight heparin (LMWH) offers a favorable risk/benefit ratio, except in neonates at high hemorrhagic risk. Conclusion: Neonatal intracardiac thrombosis, though rare, requires high clinical suspicion and prompt multidisciplinary management. Early diagnosis and individualized anticoagulant therapy can lead to favorable outcomes while minimizing complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.