Evidence map›Paper›PMID 40842465›Full record

ArticleOncology letters2025

Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report.

Ioannis Ntanasis-Stathopoulos, Ilias Katsadouros, Panagiotis Malandrakis, Erasmia Psimenou, Meletios-Athanasios Dimopoulos, Maria Gavriatopoulou

Abstract readCase Reports
In one paragraph

Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioannis Ntanasis-StathopoulosPlasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Ilias KatsadourosPlasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Panagiotis MalandrakisPlasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Erasmia PsimenouPlasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Meletios-Athanasios DimopoulosPlasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Maria GavriatopoulouPlasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teclistamab, a B-cell maturation antigen-targeting bispecific antibody, offers a promising treatment option for relapsed/refractory multiple myeloma (RRMM), even in patients with severe renal impairment. The present study describes the case of a 47-year-old woman with RRMM who achieved minimal residual disease negativity and dialysis independence following teclistamab treatment. Despite prior resistance to multiple therapies, including an anti-CD38 monoclonal antibody (daratumumab), two proteasome inhibitors (bortezomib and carfilzomib), an immunomodulatory drug (lenalidomide), an exportin 1 inhibitor (selinexor), a BCL-2 inhibitor (venetoclax) and dexamethasone, and post-autologous stem cell transplantation relapse, teclistamab induced a deep hematological response. Cytokine release syndrome was manageable and no major complications occurred. The present case highlights the feasibility and effectiveness of teclistamab in patients with end-stage renal disease.

Indexed as

B-cell maturation antigenbispecific antibodydialysismultiple myelomarelapsed/refractoryrenal impairmentteclistamab

Identifiers

PMID40842465
PMCPMC12365885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.