Evidence map›Paper›PMID 40842442›Full record

ArticlePharmacology research & perspectives2025

6-Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation.

José Britto-Júnior, Pérola Rafaella Cedano Godoy, Denis Oliveira Lima, Valéria B de Souza, André A Schenka, Fernanda V Mariano, Felipe Fernandes Jacintho, Idam Hermawan, Hiroaki Shimokawa, Masato Tsutsui and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

José Britto-JúniorDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0003-0250-8468
Pérola Rafaella Cedano GodoyDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Denis Oliveira LimaDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Valéria B de SouzaDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
André A SchenkaDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Fernanda V MarianoDepartment of Pathology, Faculty of Medical Science, State University of Campinas (UNICAMP), Campinas, Brazil.
Felipe Fernandes JacinthoDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Idam HermawanDepartment of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Hiroaki ShimokawaGraduate School, International University of Health and Welfare, Narita, Japan.
Masato TsutsuiDepartment of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Silvana ChiavegattoDepartment of Pharmacology, Institute of Biomedical Sciences (ICB), University of Sao Paulo (USP), São Paulo, Brazil.
Edson AntunesDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Gilberto De NucciDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/06100-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/15175-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/16805-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/14414-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/17468-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10306-4
6 · The paper itself

Abstract

Human seminal vesicles present basal release of epithelium-derived 6-nitrodopamine (6-ND) and this catecholamine potentiates noradrenaline-induced contractions. Since nitric oxide synthase (NOS) activation is a determining factor involved in 6-ND biosynthesis, this study aimed to investigate which NOS isoform is responsible for the 6-ND release in mouse isolated seminal vesicles (MISV). Male control, eNOS

Indexed as

DopamineNitric Oxide Synthase Type IIISeminal VesiclesAnimalsElectric StimulationMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type INitric Oxide Synthase Type IIDopamineNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIINos3 protein, mouseejaculationepithelial cellsnitrocatecholaminessynergism

Identifiers

PMID40842442
PMCPMC12371255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.